Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 10644.143 | uM | 30.49630 | 1000.00000 | -0.6190 | -0.9111 | 0.2973 | 0.4566 | 0.6009 | 0.6221 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 10874.143 | uM | 767.35840 | 1000.00000 | -0.3025 | -0.2570 | 1.5664 | 0.2339 | 0.7658 | 0.7639 | |
| HCC1937 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 11849.143 | uM | 475.98340 | 554.27760 | 0.0804 | -0.0680 | 0.8376 | 0.1832 | 0.9881 | 1.3433 | |
| MDA-MB-453 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 12414.143 | uM | inf | inf | -0.0733 | -0.0733 | 0.0000 | 0.3852 | 0.5556 | 1.1898 | |
| T47DKBLUC | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 12608.143 | uM | 1091.99560 | 1000.00000 | 0.1517 | 0.0345 | 0.8117 | 0.1640 | 0.840 | 1.1322 | |
| HCC1419 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 12001.143 | uM | 815.0230 | 1000.00000 | 0.1551 | -0.0348 | 0.3288 | 0.2369 | 0.7161 | 0.6160 | |
| LY2 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12319.143 | uM | 0.45281 | 3.81640 | -0.9874 | -1.0000 | 0.5154 | 1.1295 | 0.8727 | 0.5178 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10818.143 | uM | 6.06410 | 1000.00000 | -0.4041 | -0.9489 | 0.2084 | 0.5572 | 0.8336 | 0.6263 | |
| LY2 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10816.143 | uM | 8.28680 | 13.63060 | -0.9893 | -0.9266 | 2.1068 | 0.8679 | 0.9929 | 0.4975 | |
| CAMA-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10755.143 | uM | 8.13980 | 33.83090 | 0.0811 | -0.1496 | 0.1837 | 0.5019 | 0.6967 | 0.9034 | |
| HCC1187 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10753.143 | uM | 89.89790 | 1000.00000 | -0.1974 | -0.5152 | 0.2940 | 0.3648 | 0.7850 | 1.4954 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12126.143 | uM | 0.47434 | 0.49747 | -0.4005 | -0.0875 | 3.3888 | 0.7850 | 0.8672 | 0.6729 | |
| HCC1954 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 11055.143 | uM | 147.76320 | 895.75930 | -0.2584 | -0.7499 | 0.5084 | 0.3133 | 0.9879 | 1.7215 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 12192.143 | uM | 875.95260 | 1000.00000 | -0.0499 | -0.1056 | 1.4465 | 0.1455 | 0.9340 | 0.5995 | |
| MDA-MB-415 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12333.143 | uM | 69.31480 | 1000.00000 | -0.2174 | -0.7755 | 0.3509 | 0.4155 | 0.8044 | 0.6265 | |
| 184B5 | NM | Basal | 5-DFUR | TYMS | TYMS | 12566.143 | uM | 303.43380 | 999.99910 | 0.1514 | -0.2734 | 0.3658 | 0.2766 | 0.9906 | 1.6413 | |
| HCC1395 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 12000.143 | uM | 84.36160 | 1000.00000 | -0.3079 | -0.7342 | 0.3654 | 0.3948 | 0.8405 | 0.8939 | |
| HCC1143 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 12112.143 | uM | 129.51890 | 410.77330 | -0.0337 | -0.3158 | 0.4242 | 0.3100 | 0.9533 | 1.6893 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10642.143 | uM | 7.22710 | 325.88040 | -0.5472 | -1.0000 | 0.2885 | 0.6114 | 0.8883 | 0.5076 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 9118.017 | uM | 78.35630 | 305.35030 | -0.9327 | -1.0000 | 0.8077 | 0.6926 | 0.9801 | 1.0401 | |
| MDA-MB-415 | HR+ | Luminal | 5-FU | TYMS | TYMS | 7897.035 | uM | 199.69580 | 698.60690 | -0.7189 | -0.8653 | 0.8021 | 0.5067 | 0.9935 | 0.8378 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-FU | TYMS | TYMS | 7885.017 | uM | 68.30750 | 288.83820 | -0.9570 | -1.0000 | 0.7620 | 0.6648 | 0.9889 | 0.5647 | |
| MDA-MB-157 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7879.017 | uM | 915.45150 | 1000.00000 | 0.0233 | -0.0364 | 0.7947 | 0.2302 | 0.9921 | 1.7754 | |
| Hs 578T | TNBC | Basal B | 5-FU | TYMS | TYMS | 7863.017 | uM | 60.73160 | 142.34260 | -0.4110 | -0.4799 | 0.7899 | 0.5666 | 0.9892 | 1.9568 | |
| Hs 578T | TNBC | Basal B | 5-FU | TYMS | TYMS | 7864.017 | uM | 56.13570 | 165.52520 | -0.5570 | -0.6452 | 0.7664 | 0.6230 | 0.9857 | 1.6561 |