Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Triciribine | AKT | AKT | 7494.074 | uM | 0.43155 | 0.25258 | 0.2066 | 0.1165 | 0.4950 | 0.3473 | 0.9907 | 0.6767 | |
| MDA-MB-157 | TNBC | Basal B | Triciribine | AKT | AKT | 7495.074 | uM | 3.20830 | 73.02160 | 0.0644 | -1.0000 | 0.3516 | 0.2590 | 0.9067 | 1.1729 | |
| HCC1937 | TNBC | Basal A | Triciribine | AKT | AKT | 7453.074 | uM | 13.45240 | 3.36860 | 0.4128 | 0.3099 | 0.6986 | 0.1200 | 0.9719 | 1.5871 | |
| 600MPE | HR+ | Luminal | Triciribine | AKT | AKT | 5898.074 | uM | 0.57767 | 3.96870 | -0.0423 | -0.5354 | 0.3777 | 0.3788 | 0.9668 | 0.7134 | |
| MDA-MB-453 | TNBC | Luminal | Triciribine | AKT | AKT | 7517.074 | uM | 0.13283 | 0.24464 | 0.0317 | -0.1306 | 0.3800 | 0.4546 | 0.9905 | 1.5337 | |
| BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12291.165 | uM | 0.08918 | 0.66991 | -0.9980 | -1.0000 | 0.5448 | 0.8274 | 0.8520 | 0.5602 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 7493.074 | uM | 0.12436 | 0.26451 | -0.3977 | -0.4199 | 0.8079 | 0.5445 | 0.9983 | 1.1549 | |
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 12070.158 | uM | 2.60090 | 7.86290 | -0.8870 | -1.0000 | 0.9931 | 0.3840 | 0.9790 | 1.1252 | |
| MCF7 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10997.153 | uM | 1.66070 | 4.34240 | -0.9658 | -1.0000 | 1.1430 | 0.4990 | 0.9842 | 1.0771 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 7492.074 | uM | 0.27441 | 0.34225 | -0.0961 | -0.1118 | 0.9138 | 0.4035 | 0.9951 | 1.4222 | |
| BT-20 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10581.141 | uM | 5.68520 | 11.73980 | -0.9996 | -1.0000 | 1.5151 | 0.3224 | 0.9843 | 0.6310 | |
| AU565 | HER2amp | Luminal | Triciribine | AKT | AKT | 5900.074 | uM | 0.07721 | 0.15941 | -0.5051 | -0.5223 | 0.9865 | 0.6448 | 0.9219 | 2.4189 | |
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10473.141 | uM | 5.97870 | 15.75880 | -0.6868 | -1.0000 | 1.1335 | 0.3294 | 0.9551 | 1.2804 | |
| HCC1569 | HER2amp | Basal A | Triciribine | AKT | AKT | 7447.074 | uM | 4.59260 | 1000.00000 | 0.3985 | -0.6705 | 0.1580 | 0.3206 | 0.8409 | 1.5411 | |
| HCC1569 | HER2amp | Basal A | Triciribine | AKT | AKT | 7448.074 | uM | inf | 4.66670 | 0.6704 | 0.5030 | 0.3643 | 0.1183 | 0.9882 | 2.8830 | |
| HCC1569 | HER2amp | Basal A | Triciribine | AKT | AKT | 7449.074 | uM | inf | 3.22310 | 0.6008 | 0.4529 | 0.4257 | 0.1312 | 0.9912 | 2.0321 | |
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10755.153 | uM | 10.12190 | 11.78250 | -0.5684 | -0.5687 | 5.0000 | 0.2778 | 0.9603 | 0.7471 | |
| HCC3153 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10577.141 | uM | 8.0270 | 56.07330 | -0.0634 | -1.0000 | 0.5652 | 0.2508 | 0.9124 | 0.9203 | |
| MDA-MB-134-VI | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10998.153 | uM | 7.28970 | 15.73960 | -0.9847 | -1.0000 | 1.4273 | 0.3349 | 0.9248 | 0.7434 | |
| HCC1569 | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 10872.153 | uM | 9.73860 | 17.79130 | -0.8670 | -1.0000 | 1.8231 | 0.2406 | 0.9913 | 1.5576 | |
| BT-474 | HER2amp | Luminal | Triciribine | AKT | AKT | 5905.074 | uM | 0.07957 | 0.15194 | -0.2667 | -0.3062 | 0.7386 | 0.5707 | 0.9369 | 0.8648 | |
| HCC1569 | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 12523.165 | uM | 8.57050 | 18.45990 | -0.5139 | -0.8139 | 1.2592 | 0.2049 | 0.9973 | 1.0249 | |
| MCF12A | NM | Basal B | Sigma A6730 | AKT | AKT | 12365.165 | uM | 13.69190 | 22.9060 | -0.8300 | -1.0000 | 2.1349 | 0.1831 | 0.9923 | 1.9114 | |
| HCC1954 | HER2amp | Basal A | Triciribine | AKT | AKT | 7456.074 | uM | 29.61170 | 12.73430 | 0.4776 | 0.1603 | 0.4579 | 0.1316 | 0.9387 | 1.9647 | |
| BT-483 | HR+ | Luminal | Triciribine | AKT | AKT | 5908.074 | uM | 0.01754 | 0.14176 | -0.3535 | -0.5337 | 0.3476 | 0.6743 | 0.9586 | 0.5224 |