Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | 2-deoxyglucose | 12949.177 | uM | 1068.11960 | 999.58210 | 0.1328 | 0.1289 | 4.4961 | 0.1401 | 0.8220 | 1.7727 | |||
| CAMA-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10473.138 | uM | inf | 1.19780 | 0.7189 | 0.7475 | 4.9965 | 0.0394 | 0.9219 | 1.2872 | ||
| CAMA-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 12070.16 | uM | 1.30120 | 1.15090 | 0.2168 | 0.2294 | 4.9999 | 0.2666 | 0.9242 | 0.8453 | ||
| HCC1806 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7830.016 | uM | inf | inf | 0.2581 | 0.2581 | 0.0000 | 0.1910 | 0.3538 | 2.0313 | ||
| HCC1806 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7829.016 | uM | 13.43190 | 18.22980 | -0.8442 | -0.8456 | 3.2414 | 0.3225 | 0.9995 | 1.9532 | ||
| SUM159PT | TNBC | Basal B | Ribavirin | 15402.211 | uM | 51.66870 | 999.82030 | 0.4628 | -0.6950 | 0.2941 | 0.1569 | 0.8782 | 3.0887 | |||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7793.016 | uM | 42.57250 | 65.16510 | -0.8497 | -1.0000 | 2.5806 | 0.2359 | 0.9519 | 1.1616 | ||
| HCC1806 | TNBC | Basal A | 2-deoxyglucose | 12702.177 | uM | 556.93120 | 1000.00000 | -0.1052 | -0.4162 | 1.0348 | 0.1905 | 0.9832 | 1.5730 | |||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9648.026 | uM | 128.35510 | 1000.00000 | -0.2701 | -0.5737 | 0.3723 | 0.3304 | 0.7969 | 0.7065 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 7895.018 | uM | 202.80460 | 1000.00000 | -0.8635 | -1.0000 | 0.6886 | 0.3918 | 0.7644 | 1.2916 | ||
| HCC2185 | TNBC | Luminal | Ribavirin | 15306.211 | uM | inf | inf | 0.9179 | 0.9179 | 0.0000 | 0.0789 | 0.0000 | 0.4935 | |||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 10095.034 | uM | 45.56020 | 1000.00000 | -0.6337 | -0.9350 | 0.3414 | 0.4082 | 0.6725 | 0.7874 | ||
| MDA-MB-361 | HER2amp | Luminal | Chloroquine | 12989.177 | uM | 0.07044 | 0.07617 | -1.0000 | -0.2394 | 5.0000 | 0.6207 | 0.6940 | 0.3765 | |||
| MX1 | Unknown | Unknown | Ibandronate | FDPS | 10644.143 | uM | 70.98440 | 315.23990 | -0.4930 | -1.0000 | 0.7369 | 0.4141 | 0.8107 | 0.6221 | ||
| MX1 | Unknown | Unknown | Ibandronate | FDPS | 12220.143 | uM | 51.18350 | 329.6960 | -0.5371 | -1.0000 | 0.5898 | 0.4324 | 0.6251 | 0.4532 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7899.018 | uM | 667.12150 | 1000.00000 | 0.1240 | -0.0951 | 0.4301 | 0.2248 | 0.8264 | 2.0432 | ||
| SUM159PT | TNBC | Basal B | TAPI-0 | TACE/Collagenase | 7531.096 | uM | inf | inf | 0.8694 | 0.8694 | 0.0000 | 0.0391 | 0.3982 | 3.5504 | ||
| CAMA-1 | HR+ | Luminal | Ibandronate | FDPS | 10755.143 | uM | 93.02980 | 186.9680 | -0.7925 | -0.8809 | 1.4554 | 0.3745 | 0.9695 | 0.9034 | ||
| CAMA-1 | HR+ | Luminal | Ibandronate | FDPS | 12070.143 | uM | 209.3390 | 252.68780 | -0.7810 | -0.7813 | 5.0000 | 0.2384 | 0.9969 | 0.9561 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7900.018 | uM | inf | inf | -0.7506 | -0.7506 | 0.0000 | 0.4724 | 0.5038 | 0.8304 | ||
| HCC1937 | TNBC | Basal A | Nelfinavir | 13115.174 | uM | 6.86140 | 8.82710 | -0.9981 | -1.0000 | 4.3611 | 0.1920 | 0.9948 | 0.8122 | |||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7902.018 | uM | 788.84610 | 1000.00000 | 0.1746 | -0.0490 | 0.3938 | 0.2081 | 0.7743 | 1.8686 | ||
| MDA-MB-157 | TNBC | Basal B | Mebendazole | 12632.174 | uM | 0.47426 | 1.51290 | -0.7326 | -0.7913 | 0.8179 | 0.5406 | 0.9867 | 0.8563 | |||
| HCC1806 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 9376.026 | uM | 41.79070 | 248.34420 | -0.9007 | -1.0000 | 0.6165 | 0.5604 | 0.8770 | 1.6827 | ||
| HCC1806 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 7830.018 | uM | 220.51760 | 382.13150 | -0.9259 | -0.9553 | 1.9432 | 0.4203 | 0.9868 | 1.5320 |