Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7811.001 | uM | 0.01148 | 0.01402 | -0.9576 | -0.8571 | 5.0000 | 1.0993 | 0.9874 | 0.4464 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10816.15 | uM | 21.64110 | 26.9580 | -0.4840 | -0.9997 | 5.0000 | 0.0458 | 0.9904 | 0.3031 | |
| BT-474 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9158.001 | uM | 5.49390 | 8.17950 | -0.9752 | -1.0000 | 2.7604 | 0.2511 | 0.9873 | 0.6988 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12178.16 | uM | inf | inf | 0.5577 | 0.5577 | 0.0000 | 0.3142 | 0.4077 | 0.7392 | |
| CAMA-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10755.15 | uM | inf | inf | 0.2169 | 0.2169 | 0.0000 | 0.2802 | 0.2284 | 0.7807 | |
| HCC1569 | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12523.169 | uM | 1.51170 | 10.62030 | -0.8801 | -1.0000 | 0.5635 | 0.4311 | 0.9141 | 1.0498 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 12365.169 | uM | inf | 0.64004 | 0.6059 | 0.6378 | 3.4420 | 0.1185 | 0.9695 | 2.1831 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 7875.001 | uM | 8.04810 | 10.02270 | -0.9646 | -0.9700 | 4.9151 | 0.1240 | 0.9964 | 1.4600 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 7877.001 | uM | 0.29497 | 4.43060 | -0.4638 | -1.0000 | 0.4055 | 0.4308 | 0.9496 | 0.4366 | |
| MCF 10F | NM | - | ZM-447439 | AURK | AURK | 12254.16 | uM | inf | 2.36150 | 0.5734 | 0.7090 | 5.0000 | 0.0457 | 0.7984 | 1.4029 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 7813.001 | uM | 5.56960 | 8.06020 | -0.9735 | -1.0000 | 2.9723 | 0.1992 | 0.9944 | 0.7338 | |
| MCF12A | NM | Basal B | GSK1070916 | AURK | AURK | 10061.001 | uM | 7.05180 | 18.47620 | -0.3544 | -1.0000 | 1.1406 | 0.2085 | 0.9378 | 1.7406 | |
| HCC2185 | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10996.15 | uM | 0.22479 | 0.19030 | 0.0203 | 0.1302 | 1.8105 | 0.3260 | 0.9140 | 0.5092 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9035.001 | uM | 3.31290 | 213.70830 | 0.1236 | -1.0000 | 0.2637 | 0.2641 | 0.8354 | 2.4291 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 7816.001 | uM | 0.59860 | 2.77790 | -0.9806 | -1.0000 | 0.7158 | 0.4383 | 0.9545 | 1.0243 | |
| MCF 10F | NM | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12254.16 | uM | 8.0680 | 8.73180 | -0.1701 | -0.1770 | 3.8335 | 0.0845 | 0.9915 | 1.4029 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10696.15 | uM | inf | inf | 0.4427 | 0.4427 | 0.0000 | 0.1816 | 0.5138 | 0.4740 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10581.138 | uM | 5.16160 | 30.74760 | -0.4765 | -1.0000 | 0.6156 | 0.3418 | 0.9196 | 0.9462 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 11854.16 | uM | 7.8450 | 6.64530 | 0.3364 | 0.0291 | 0.3615 | 0.2804 | 0.8971 | 1.3102 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 11855.16 | uM | inf | inf | 0.5429 | 0.5429 | 0.0000 | 0.3123 | 0.0079 | 0.6477 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9254.001 | uM | 5.38610 | 6.70950 | -1.0000 | -0.9998 | 5.0000 | 0.3079 | 0.9082 | 0.3986 | |
| AU565 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 10880.15 | uM | inf | 0.49203 | 0.4211 | 0.5508 | 2.4406 | 0.1717 | 0.8585 | 1.5829 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 7825.001 | uM | 0.64893 | 4.17490 | -0.7698 | -1.0000 | 0.5902 | 0.4203 | 0.9327 | 1.5991 | |
| HCC2185 | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12192.16 | uM | 0.35927 | 0.12565 | 0.2935 | 0.3575 | 1.1951 | 0.2654 | 0.8281 | 0.7363 | |
| HCC2185 | TNBC | Luminal | ZM-447439 | AURK | AURK | 12192.16 | uM | 1.27190 | 0.63873 | 0.1767 | 0.2379 | 0.9378 | 0.3421 | 0.9088 | 0.7363 |