Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MX1
Unknown
Unknown
 Fascaplysin
CDK4
CDK
7523.084
uM
0.2830
0.38925
 -0.9917 -1.0000 3.4462 0.7612
0.9801
 0.9069
HCC1419
HER2amp
Luminal
 Carboplatin
DNA cross-linker
DNA cross-linker
10019.12
uM
43.09170
78.77850
 -0.9916 -0.9762 1.7945 0.4068
0.9964
 0.4898
MDA-MB-175-VII
HR+
Luminal
 Oxamflatin
HDAC
HDAC
12126.147
uM
2.58410
7.95250
 -0.9916 -1.0000 0.9773 0.4674
0.9014
 0.7140
CAMA-1
HR+
Luminal
 Methylglyoxal
13157.184
uM
532.38820
1000.00000
 -0.9916 -0.5508 1.1782 0.3945
0.8666
 0.8492
HCC38
TNBC
Basal B
 Epirubicin
TOP2
TOP
7854.017
uM
0.05337
0.09941
 -0.9916 -0.8379 1.5823 1.0585
0.9869
 1.3102
SUM1315MO2
TNBC
Basal B
 Sirolimus
MTOR
MTOR
7529.068
uM
0.18707
4.90180
 -0.9916 -1.0000 0.3364 0.6856
0.7828
 0.6347
MCF7
HR+
Luminal
 Imatinib
ABL/KIT/PDGFR
nRTK
7493.091
uM
14.0360
24.28710
 -0.9916 -1.0000 2.0036 0.4981
0.9975
 1.0859
HCC3153
TNBC
Basal A
 Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
7466.067
uM
10.08160
13.52150
 -0.9915 -0.9914 3.7228 0.3582
0.9977
 0.9457
UACC-812
HER2amp
Luminal
 IKK16
IKK
NFKB
10580.1
uM
5.03630
6.27380
 -0.9915 -1.0000 5.0000 0.4828
0.9665
 0.7968
SUM225CWN
HER2amp
Basal A
 Fascaplysin
CDK4
CDK
7533.084
uM
0.09404
0.14063
 -0.9915 -0.9787 2.6949 0.8471
0.9981
 1.0396
HMT-3522 S1
Unknown
Unknown
 Epirubicin
TOP2
TOP
7911.017
uM
0.39366
0.66727
 -0.9915 -0.7303 1.7063 0.7212
0.9778
 1.6151
HCC70
TNBC
Basal A
 AG1478
EGFR
ErbB
7860.016
uM
4.60020
18.35640
 -0.9915 -1.0000 0.7939 0.3786
0.9507
 0.6145
BT-483
HR+
Luminal
 Vinorelbine
TUBB
TUBB
7801.018
uM
0.01410
0.02251
 -0.9914 -0.5604 1.6079 0.9036
0.9338
 0.5913
MDA-MB-361
HER2amp
Luminal
 Vorinostat
HDAC
HDAC
7508.065
uM
44.19490
88.7310
 -0.9914 -1.0000 1.5762 0.8387
0.9977
 0.7854
SUM185PE
TNBC
Luminal
 Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
7532.067
uM
0.94581
3.07770
 -0.9914 -1.0000 0.9311 0.7010
0.9750
 0.9744
HCC1187
TNBC
Basal A
 Imatinib
ABL/KIT/PDGFR
nRTK
7433.09
uM
24.5410
32.46660
 -0.9914 -0.9975 3.9195 0.4067
0.9962
 0.8477
MDA-MB-134-VI
HR+
Luminal
 Oxamflatin
HDAC
HDAC
10998.147
uM
0.63034
2.19980
 -0.9914 -1.0000 0.8790 0.5773
0.9915
 0.8573
MDA-MB-175-VII
HR+
Luminal
 Valproic acid
HDAC
HDAC
12126.143
uM
436.90840
1000.00000
 -0.9913 -0.6358 0.9909 0.4127
0.7381
 0.6729
ZR-75-1
HR+
Luminal
 CGC-11047
Polyamine analogue
9958.034
uM
39.0970
428.03390
 -0.9912 -1.0000 0.4591 0.4917
0.8402
 0.5217
HCC1428
HR+
Luminal
 Bosutinib
Src
nRTK
10693.145
uM
2.7610
5.72950
 -0.9912 -1.0000 1.5049 0.5196
0.9752
 0.8492
HCC1428
HR+
Luminal
 Temsirolimus
MTOR
MTOR
10693.144
uM
0.45772
9.90080
 -0.9911 -1.0000 0.3574 0.5735
0.7381
 0.8585
MDA-MB-415
HR+
Luminal
 Disulfiram
Proteasome
Proteasome
13587.174
uM
12.5020
17.09140
 -0.9911 -1.0000 3.5135 0.2860
0.9699
 0.6955
MDA-MB-453
TNBC
Luminal
 Doxorubicin
TOP2
TOP
9723.121
uM
0.22157
0.32961
 -0.9910 -0.9066 2.6041 0.8287
0.9948
 0.9445
CAMA-1
HR+
Luminal
 Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
5911.067
uM
7.6070
9.77620
 -0.9909 -0.9918 4.3572 0.4414
0.9968
 1.0037
SUM185PE
TNBC
Luminal
 NSC 663284
CDC25
CDC
12269.152
uM
0.28492
0.80724
 -0.9909 -1.0000 1.0549 0.8215
0.9829
 0.8791