Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9163.026 | uM | 1.16670 | 17.90580 | -1.0000 | -1.0000 | 0.4023 | 0.8897 | 0.9004 | 0.3738 | ||
| HCC1419 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7440.091 | uM | 13.33510 | 25.14190 | -1.0000 | -1.0000 | 1.7325 | 0.5992 | 0.9458 | 0.4250 | |
| 600MPE | HR+ | Luminal | Chloroquine | 13091.177 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 0.3682 | 0.5443 | 0.7004 | |||
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9254.001 | uM | 0.00450 | 0.00522 | -1.0000 | -0.5435 | 5.0000 | 1.0717 | 0.8911 | 0.3986 | |
| HCC1419 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 7437.084 | uM | 0.25725 | 0.39177 | -1.0000 | -1.0000 | 2.6118 | 0.7425 | 0.9852 | 0.4343 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 12979.177 | uM | 0.02740 | 0.03413 | -1.0000 | -1.0000 | 5.0000 | 1.0789 | 0.9988 | 0.5647 | |
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9258.026 | uM | 0.44087 | 35.50130 | -1.0000 | -1.0000 | 0.2503 | 0.8247 | 0.7494 | 0.5632 | ||
| HCC1419 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9278.026 | uM | 1.04710 | 16.32940 | -1.0000 | -1.0000 | 0.3999 | 0.9084 | 0.9403 | 0.3395 | ||
| HCC1187 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7811.044 | uM | 11.65150 | 16.05880 | -1.0000 | -0.9995 | 3.4233 | 0.3459 | 0.9975 | 0.3073 | ||
| HCC1187 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7811.011 | uM | 0.26894 | 0.77535 | -1.0000 | -1.0000 | 1.0376 | 1.1173 | 0.9558 | 0.4400 | |
| HCC1187 | TNBC | Basal A | Methylglyoxal | 13726.184 | uM | 0.99124 | 16.40040 | -1.0000 | -1.0000 | 0.3915 | 1.2606 | 0.7991 | 0.3574 | |||
| HCC1187 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7811.04 | uM | 1.04690 | 1.38930 | -1.0000 | -0.9258 | 3.7023 | 0.7792 | 0.8482 | 0.3921 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7821.017 | uM | 0.78388 | 0.97271 | -1.0000 | -0.9710 | 5.0000 | 0.7996 | 0.9985 | 0.3792 | |
| HCC1187 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7811.017 | uM | 1.68090 | 2.53690 | -1.0000 | -1.0000 | 2.6690 | 0.9047 | 0.7309 | 0.3604 | |
| 184A1 | NM | Basal | Doxorubicin | TOP2 | TOP | 10002.034 | uM | 0.10668 | 0.20741 | -1.0000 | -0.9682 | 1.6201 | 0.9516 | 0.9936 | 0.6736 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9258.03 | uM | 1.05110 | 2.06760 | -1.0000 | -1.0000 | 1.6238 | 0.7227 | 0.9985 | 0.4015 | |
| HCC202 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7458.095 | uM | 0.00675 | 0.01005 | -1.0000 | -0.9159 | 2.6174 | 1.2208 | 0.9968 | 0.3752 | |
| HCC2185 | TNBC | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7848.011 | uM | 22.99330 | 53.01150 | -1.0000 | -0.9999 | 1.3151 | 0.4841 | 0.9976 | 0.3405 | |
| 184B5 | NM | Basal | Chloroquine | 12979.177 | uM | 19.64650 | 24.47430 | -1.0000 | -1.0000 | 5.0000 | 0.1512 | 0.9526 | 0.5647 | |||
| BT-474 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9158.049 | uM | 1.82990 | 2.5510 | -1.0000 | -0.9995 | 3.3059 | 0.5005 | 0.9072 | 0.4082 | |
| HCC1187 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 9244.021 | uM | 2.02180 | 2.59060 | -1.0000 | -0.9970 | 4.4235 | 0.7319 | 0.9785 | 0.4542 | |
| BT-474 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 13125.177 | uM | 0.37090 | 0.53838 | -1.0000 | -0.9928 | 2.9354 | 0.6307 | 0.9967 | 0.8991 | |
| AU565 | HER2amp | Luminal | Methylglyoxal | 13030.184 | uM | 50.30640 | 183.32630 | -1.0000 | -1.0000 | 0.8496 | 0.9024 | 0.9717 | 0.5725 | |||
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7477.071 | uM | 0.62597 | 1.35510 | -1.0000 | -0.9841 | 1.4086 | 0.6625 | 0.9893 | 0.5122 | |
| Hs 578T | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7471.092 | uM | 3.33160 | 4.13810 | -1.0000 | -0.9781 | 5.0000 | 0.8415 | 0.9628 | 0.3860 |