Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 9186.001 | uM | 4.77160 | 14.99120 | -0.3723 | -1.0000 | 0.9597 | 0.2294 | 0.9503 | 0.5165 | |
| BT-549 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 5909.093 | uM | 8.68780 | 13.67080 | -0.7946 | -1.0000 | 2.4234 | 0.1284 | 0.9953 | 2.8805 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10581.138 | uM | 5.16160 | 30.74760 | -0.4765 | -1.0000 | 0.6156 | 0.3418 | 0.9196 | 0.9462 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 11855.161 | uM | 6.06830 | 274.20550 | 0.0925 | -1.0000 | 0.2883 | 0.2708 | 0.7203 | 0.5957 | |
| AU565 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9146.049 | uM | 0.27923 | 2.3090 | -0.7753 | -1.0000 | 0.5201 | 0.5661 | 0.8221 | 1.1054 | |
| CAMA-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 9210.001 | uM | 8.02190 | 17.5930 | -0.4354 | -1.0000 | 1.3989 | 0.2132 | 0.9502 | 0.8761 | |
| BT-474 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 12291.168 | uM | 6.40940 | 16.7950 | -0.9999 | -1.0000 | 1.1405 | 0.4929 | 0.8676 | 0.4466 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10581.138 | uM | 2.27850 | 21.40780 | -0.6125 | -1.0000 | 0.4904 | 0.4054 | 0.8601 | 0.9462 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 5906.065 | uM | 39.50840 | 80.74350 | -0.9927 | -1.0000 | 1.5370 | 0.8548 | 0.9977 | 0.6586 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9158.001 | uM | 0.73737 | 3.63920 | -0.9931 | -1.0000 | 0.6882 | 0.4173 | 0.8979 | 0.6988 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 11855.147 | uM | 0.89533 | 3.02110 | -0.9707 | -1.0000 | 0.9033 | 0.6208 | 0.9123 | 0.5719 | |
| AU565 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 10880.15 | uM | 9.07190 | 75.67630 | 0.2009 | -1.0000 | 0.5179 | 0.1669 | 0.9797 | 1.5829 | ||
| 184B5 | NM | Basal | Vorinostat | HDAC | HDAC | 5896.065 | uM | 114.54920 | 884.06290 | -0.8093 | -1.0000 | 0.5376 | 0.5272 | 0.9847 | 1.4978 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9146.001 | uM | 2.55360 | 9.30180 | -0.6291 | -1.0000 | 0.8499 | 0.3663 | 0.8348 | 1.2878 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9035.001 | uM | 3.31290 | 213.70830 | 0.1236 | -1.0000 | 0.2637 | 0.2641 | 0.8354 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7793.001 | uM | 5.6020 | 10.09590 | -0.8129 | -1.0000 | 1.8652 | 0.2425 | 0.9715 | 1.1508 | |
| BT-549 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 9024.016 | uM | 28.2640 | 91.15930 | 0.4348 | -1.0000 | 0.9382 | 0.0677 | 0.9839 | 3.2430 | |
| BT-483 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 10696.072 | uM | 43.20790 | 124.21610 | -0.1623 | -1.0000 | 1.0404 | 0.2141 | 0.8327 | 0.4643 | |
| BT-474 | HER2amp | Luminal | Nelfinavir | 13125.174 | uM | 10.470 | 16.79570 | -0.6639 | -1.0000 | 2.3245 | 0.2049 | 0.9671 | 0.9685 | |||
| 184A1 | NM | Basal | Imatinib | ABL/KIT/PDGFR | nRTK | 5895.091 | uM | 16.09010 | 26.49230 | -0.9899 | -1.0000 | 2.2032 | 0.4630 | 0.9969 | 1.1729 | |
| BT-549 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 12305.165 | uM | 12.39490 | 20.55540 | -0.8811 | -1.0000 | 2.1719 | 0.2542 | 0.9818 | 2.7020 | |
| BT-474 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9163.001 | uM | 2.92570 | 5.91270 | -0.9570 | -1.0000 | 1.5615 | 0.3033 | 0.9699 | 0.5227 | |
| HCC1143 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 12112.161 | uM | 95.97580 | 456.18670 | 0.4862 | -1.0000 | 0.7048 | 0.1069 | 0.7799 | 1.7182 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 10031.001 | uM | 7.23950 | 9.99140 | -0.9807 | -1.0000 | 3.4100 | 0.2079 | 0.980 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9294.001 | uM | 3.17740 | 8.92350 | -0.6549 | -1.0000 | 1.0639 | 0.3056 | 0.9387 | 0.7859 |