Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
184A1 | NM | Basal | Imatinib | ABL/KIT/PDGFR | nRTK | 5895.091 | uM | 16.09010 | 26.49230 | -0.9899 | -1.0000 | 2.2032 | 0.4630 | 0.9969 | 1.1729 | |
184A1 | NM | Basal | L-779450 | BRAF | MAPK | 12509.166 | uM | 8.56520 | 14.40640 | -0.7107 | -1.0000 | 2.1129 | 0.1672 | 0.9687 | 1.2847 | |
184B5 | NM | Basal | AS-252424 | PI3K | PI3K | 12566.165 | uM | 26.52190 | 125.8320 | 0.4159 | -1.0000 | 0.7056 | 0.0982 | 0.8944 | 1.7248 | |
184A1 | NM | Basal | GSK461364 | PLK1 | PLK | 10002.001 | uM | 6.06620 | 9.11620 | -0.9717 | -1.0000 | 2.6972 | 0.2605 | 0.9735 | 0.5372 | |
184A1 | NM | Basal | GSK461364 | PLK1 | PLK | 9047.001 | uM | 4.15810 | 52.44110 | -0.0073 | -1.0000 | 0.4334 | 0.2620 | 0.7464 | 0.7701 | |
184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10002.021 | uM | 1.98010 | 5.92780 | -0.9908 | -1.0000 | 1.0019 | 0.7527 | 0.9764 | 0.7195 | |
184A1 | NM | Basal | Sigma A6730 | AKT | AKT | 12509.165 | uM | 3.14240 | 13.05610 | -0.6553 | -1.0000 | 0.7714 | 0.3161 | 0.9885 | 1.5022 | |
184A1 | NM | Basal | Nutlin 3a | MDM2 | MDM2 | 5895.066 | uM | 3.22280 | 10.22950 | -0.9725 | -1.0000 | 0.9512 | 0.3133 | 0.9559 | 1.1612 | |
184A1 | NM | Basal | Nutlin 3a | MDM2 | MDM2 | 5894.066 | uM | 6.76640 | 16.58460 | -0.8949 | -1.0000 | 1.2254 | 0.2778 | 0.9387 | 1.5027 | |
184A1 | NM | Basal | Etoposide | TOP2 | TOP | 5894.074 | uM | 9.28560 | 35.69030 | -0.7680 | -1.0000 | 0.8160 | 0.4044 | 0.9826 | 1.4541 | |
184A1 | NM | Basal | Etoposide | TOP2 | TOP | 5895.074 | uM | 10.48650 | 42.19930 | -0.7395 | -1.0000 | 0.7891 | 0.3710 | 0.9859 | 1.1218 | |
184A1 | NM | Basal | Everolimus | MTOR | MTOR | 12509.164 | uM | 0.02317 | 2.80470 | -0.9610 | -1.0000 | 0.2291 | 0.6861 | 0.6516 | 1.1949 | |
184A1 | NM | Basal | CGC-11047 | Polyamine analogue | 10002.034 | uM | 242.78660 | 399.08510 | -0.9907 | -1.0000 | 2.2105 | 0.6269 | 0.7996 | 0.6736 | ||
184A1 | NM | Basal | CGC-11047 | Polyamine analogue | 9047.026 | uM | 5.67110 | 70.62780 | -0.9997 | -1.0000 | 0.4356 | 0.7516 | 0.8174 | 0.5972 | ||
184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 5894.067 | uM | 1.62180 | 3.48940 | -0.9288 | -1.0000 | 1.4339 | 0.3983 | 0.9581 | 1.5647 | |
184A1 | NM | Basal | Afatinib | EGFR/HER2 | ErbB | 12509.165 | uM | 0.02251 | 0.33740 | -0.9088 | -1.0000 | 0.4058 | 0.8284 | 0.9307 | 1.5022 | |
184A1 | NM | Basal | GSK923295 | CENPE | Kinesin | 10002.001 | uM | 8.47170 | 11.6240 | -0.9507 | -1.0000 | 3.4729 | 0.2407 | 0.9439 | 0.5372 | |
184A1 | NM | Basal | Temsirolimus | MTOR | MTOR | 12509.168 | uM | 0.69862 | 4.34640 | -0.9247 | -1.0000 | 0.6010 | 0.6200 | 0.8824 | 1.3516 | |
184A1 | NM | Basal | Ibandronate | FDPS | 12509.143 | uM | 155.22840 | 288.34070 | -0.9140 | -1.0000 | 1.7741 | 0.2785 | 0.9964 | 1.3392 | ||
184A1 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 9047.011 | uM | 0.39288 | 3.58790 | -0.7197 | -1.0000 | 0.4967 | 0.6665 | 0.9520 | 0.6293 | |
184B5 | NM | Basal | GSK461364 | PLK1 | PLK | 9095.001 | uM | 0.17731 | 2.57920 | -0.9719 | -1.0000 | 0.4103 | 0.4637 | 0.7474 | 1.0444 | |
184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 5895.067 | uM | 2.25070 | 4.57410 | -0.9091 | -1.0000 | 1.5491 | 0.3497 | 0.9692 | 1.4053 | |
184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9047.011 | uM | 0.53932 | 2.18460 | -0.9996 | -1.0000 | 0.7854 | 0.8887 | 0.9928 | 0.6293 | |
184B5 | NM | Basal | Sigma A6730 | AKT | AKT | 12566.165 | uM | 2.97380 | 8.22950 | -0.8497 | -1.0000 | 1.0793 | 0.4028 | 0.9697 | 1.7248 | |
184B5 | NM | Basal | PD184352 | MEK | MAPK | 12566.155 | uM | 3.29320 | 33.01680 | -0.0750 | -1.0000 | 0.4766 | 0.2503 | 0.9170 | 1.5389 |