Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5896.067 | uM | 4.54790 | 8.20140 | -0.9586 | -1.0000 | 1.8632 | 0.4683 | 0.9969 | 1.4536 | |
| 184A1 | NM | Basal | GSK923295 | CENPE | Kinesin | 10002.001 | uM | 8.47170 | 11.6240 | -0.9507 | -1.0000 | 3.4729 | 0.2407 | 0.9439 | 0.5372 | |
| 600MPE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 12224.165 | uM | 8.75170 | 136.14630 | 0.2719 | -1.0000 | 0.4003 | 0.2034 | 0.8983 | 0.9714 | |
| 184A1 | NM | Basal | Temsirolimus | MTOR | MTOR | 12509.168 | uM | 0.69862 | 4.34640 | -0.9247 | -1.0000 | 0.6010 | 0.6200 | 0.8824 | 1.3516 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 5898.065 | uM | 45.55360 | 153.11150 | -0.9868 | -1.0000 | 0.9062 | 0.8120 | 0.9790 | 0.6845 | |
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7793.016 | uM | 42.57250 | 65.16510 | -0.8497 | -1.0000 | 2.5806 | 0.2359 | 0.9519 | 1.1616 | ||
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5899.098 | uM | 0.26223 | 1.66230 | -0.8751 | -1.0000 | 0.5949 | 0.6216 | 0.9891 | 1.1012 | |
| 184B5 | NM | Basal | Temsirolimus | MTOR | MTOR | 12566.168 | uM | 31.79770 | 47.19180 | -0.9110 | -1.0000 | 2.7825 | 0.3358 | 0.8544 | 1.4366 | |
| 184B5 | NM | Basal | Topotecan | TOP1 | TOP | 9095.121 | uM | 0.07632 | 0.71426 | -0.8323 | -1.0000 | 0.4913 | 0.8207 | 0.9828 | 1.1992 | |
| 184B5 | NM | Basal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12566.169 | uM | 2.34370 | 11.34480 | -0.7494 | -1.0000 | 0.6966 | 0.3916 | 0.9813 | 1.6359 | |
| 184A1 | NM | Basal | Ibandronate | FDPS | 12509.143 | uM | 155.22840 | 288.34070 | -0.9140 | -1.0000 | 1.7741 | 0.2785 | 0.9964 | 1.3392 | ||
| 600MPE | HR+ | Luminal | AG1478 | EGFR | ErbB | 7791.016 | uM | 34.63250 | 70.58790 | -0.6402 | -1.0000 | 1.5428 | 0.2456 | 0.8929 | 0.8138 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5899.07 | uM | 0.22856 | 0.81326 | -0.9610 | -1.0000 | 0.8656 | 0.6820 | 0.9966 | 0.8850 | |
| AU565 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 10880.149 | uM | 41.97630 | 133.38290 | 0.5726 | -1.0000 | 0.9503 | 0.0531 | 0.9147 | 1.6289 | |
| 600MPE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 12224.165 | uM | 6.5660 | 13.29760 | -0.9371 | -1.0000 | 1.5568 | 0.3611 | 0.9610 | 0.9714 | |
| AU565 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 10880.156 | uM | 0.57383 | 7.51240 | -0.8788 | -1.0000 | 0.4272 | 0.4508 | 0.8269 | 1.5288 | |
| 600MPE | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 12224.147 | uM | 2.79220 | 7.38130 | -0.9880 | -1.0000 | 1.1301 | 0.3828 | 0.9872 | 0.8621 | |
| 184B5 | NM | Basal | Vorinostat | HDAC | HDAC | 5896.065 | uM | 114.54920 | 884.06290 | -0.8093 | -1.0000 | 0.5376 | 0.5272 | 0.9847 | 1.4978 | |
| 184A1 | NM | Basal | IKK16 | IKK | NFKB | 5895.093 | uM | 1.01110 | 2.37210 | -0.9564 | -1.0000 | 1.2884 | 0.5085 | 0.9882 | 1.3259 | |
| AU565 | HER2amp | Luminal | NU6102 | CDK1/2 | CDK | 10880.147 | uM | 20.07910 | 29.68650 | -0.8151 | -1.0000 | 2.8097 | 0.1900 | 0.9822 | 1.5262 | |
| BT-474 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9163.001 | uM | 2.92570 | 5.91270 | -0.9570 | -1.0000 | 1.5615 | 0.3033 | 0.9699 | 0.5227 | |
| 184A1 | NM | Basal | Imatinib | ABL/KIT/PDGFR | nRTK | 5895.091 | uM | 16.09010 | 26.49230 | -0.9899 | -1.0000 | 2.2032 | 0.4630 | 0.9969 | 1.1729 | |
| 600MPE | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9120.021 | uM | 16.89330 | 40.58020 | -0.9570 | -1.0000 | 1.2536 | 0.4435 | 0.9886 | 0.6486 | |
| BT-549 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 5910.091 | uM | 110.23530 | 600.75210 | 0.6069 | -1.0000 | 0.6479 | 0.0376 | 0.9246 | 3.3208 | |
| BT-549 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 10261.026 | uM | 64.76250 | 644.36690 | -0.7483 | -1.0000 | 0.4782 | 0.4717 | 0.8595 | 2.4866 |