Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10998.154 | uM | inf | inf | 0.7776 | 0.7776 | 0.0000 | 0.1253 | -0.1381 | 0.7412 | |
| HCC1428 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10693.154 | uM | inf | inf | 0.9040 | 0.9040 | 0.0000 | 0.0850 | -0.1383 | 0.8696 | |
| MDA-MB-415 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7510.084 | uM | inf | inf | 0.8517 | 0.8517 | 0.0000 | 0.0588 | 0.1386 | 0.8702 | |
| HCC1419 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 7437.065 | uM | inf | inf | 1.0125 | 1.0125 | 0.0000 | 0.0500 | 0.1389 | 0.5183 | |
| MDA-MB-175-VII | HR+ | Luminal | Ro 32-0432 | PKC | PKC | 10642.142 | uM | inf | inf | 0.8827 | 0.8827 | 0.0000 | 0.0460 | 0.1393 | 0.5006 | |
| MDA-MB-415 | HR+ | Luminal | 2-deoxyglucose | 12959.177 | uM | inf | inf | 0.3997 | 0.3997 | 0.0000 | 0.1758 | 0.1401 | 0.5538 | |||
| ZR-75-1 | HR+ | Luminal | GM6001 | MMP | MMP | 7553.096 | uM | inf | inf | 0.8456 | 0.8456 | 0.0000 | 0.1005 | -0.1404 | 1.1407 | |
| SUM185PE | TNBC | Luminal | Dichloroacetate | PDK | PDK | 13140.176 | uM | inf | inf | 0.8118 | 0.8118 | 0.0000 | 0.0909 | -0.1414 | 0.6663 | |
| MDA-MB-453 | TNBC | Luminal | Ribavirin | 15398.211 | uM | inf | inf | 0.8982 | 0.8982 | 0.0000 | 0.0145 | 0.1417 | 1.0628 | |||
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 9566.132 | uM | inf | inf | 0.8030 | 0.8030 | 0.0000 | 0.1021 | 0.1442 | 2.4013 | ||
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 7518.067 | uM | inf | inf | 0.8749 | 0.8749 | 0.0000 | 0.2698 | -0.1447 | 0.7666 | |
| MCF 10F | NM | - | Gefitinib | EGFR | ErbB | 9566.132 | uM | inf | inf | 0.7541 | 0.7541 | 0.0000 | 0.0697 | 0.1447 | 2.4013 | |
| SUM159PT | TNBC | Basal B | Nelfinavir | 13054.174 | uM | inf | inf | 0.9613 | 0.9613 | 0.0000 | 0.0251 | 0.1450 | 3.1161 | |||
| MDA-MB-175-VII | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 12126.154 | uM | inf | inf | 0.6563 | 0.6563 | 0.0000 | 0.2735 | -0.1456 | 0.6012 | |
| SUM159PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7918.018 | uM | inf | inf | 0.9278 | 0.9278 | 0.0000 | 0.0321 | 0.1456 | 3.0213 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7492.095 | uM | inf | inf | 0.7935 | 0.7935 | 0.0000 | 0.2394 | -0.1467 | 1.0194 | |
| CAMA-1 | HR+ | Luminal | Nilotinib | ABL | nRTK | 10755.145 | uM | inf | inf | 0.9059 | 0.9059 | 0.0000 | 0.0960 | 0.1467 | 0.7688 | |
| SK-BR-3 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7527.085 | uM | inf | inf | 0.6561 | 0.6561 | 0.0000 | 0.0637 | 0.1476 | 1.9392 | |
| MDA-MB-415 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7512.065 | uM | inf | inf | 0.9567 | 0.9567 | 0.0000 | 0.0006 | 0.1478 | 0.9176 | |
| UACC-812 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 10420.072 | uM | inf | inf | 0.5919 | 0.5919 | 0.0000 | 0.1697 | 0.1494 | 0.5007 | |
| HCC1569 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 10872.152 | uM | inf | inf | 0.7580 | 0.7580 | 0.0000 | 0.1442 | 0.1498 | 1.5916 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 10938.149 | uM | inf | inf | 0.7318 | 0.7318 | 0.0000 | 0.2167 | 0.1498 | 1.0006 | |
| MDA-MB-415 | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 10938.147 | uM | inf | inf | -0.2305 | -0.2305 | 0.0000 | 0.3696 | 0.1504 | 0.9050 | |
| MDA-MB-453 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7518.065 | uM | inf | inf | 0.9324 | 0.9324 | 0.0000 | -0.0310 | -0.1509 | 1.3677 | |
| SUM185PE | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 7532.084 | uM | inf | inf | 0.8047 | 0.8047 | 0.0000 | 0.0855 | 0.1512 | 0.7770 |