Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Selumetinib | MEK | MAPK | 11854.155 | uM | inf | inf | 0.9135 | 0.9135 | 0.0000 | 0.0714 | 0.3056 | 1.3396 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9146.122 | uM | inf | inf | 0.9694 | 0.9694 | 0.0000 | -0.0404 | -1.9847 | 1.3408 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 12056.145 | uM | inf | inf | 0.9538 | 0.9538 | 0.0000 | 0.0958 | 0.3538 | 0.8365 | |
| 600MPE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12224.135 | uM | inf | inf | 0.7869 | 0.7869 | 0.0000 | 0.0993 | 0.1270 | 1.0314 | |
| 600MPE | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7791.018 | uM | inf | inf | 0.8577 | 0.8577 | 0.0000 | -0.0332 | 0.4860 | 0.8558 | |
| BT-474 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 12056.154 | uM | inf | inf | 0.7002 | 0.7002 | 0.0000 | 0.2152 | -0.1183 | 0.9136 | |
| BT-483 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 11855.154 | uM | inf | inf | 0.6553 | 0.6553 | 0.0000 | 0.2233 | 0.0021 | 0.6282 | |
| 600MPE | HR+ | Luminal | 2-deoxyglucose | 13091.177 | uM | inf | inf | 0.9504 | 0.9504 | 0.0000 | 0.3143 | 0.0580 | 0.7004 | |||
| BT-20 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 13579.176 | uM | inf | inf | 0.8837 | 0.8837 | 0.0000 | -0.0031 | 0.4777 | 0.7690 | |
| AU565 | HER2amp | Luminal | GM6001 | MMP | MMP | 5900.096 | uM | inf | inf | 0.9215 | 0.9215 | 0.0000 | 0.0442 | 0.2561 | 2.7795 | |
| 600MPE | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 12224.144 | uM | inf | inf | 0.9302 | 0.9302 | 0.0000 | 0.0839 | 0.0000 | 1.0210 | |
| 600MPE | HR+ | Luminal | AG1024 | IGF1R | RTK | 5898.066 | uM | inf | inf | 1.0423 | 1.0423 | 0.0000 | 0.0282 | 0.0610 | 0.6097 | |
| 600MPE | HR+ | Luminal | AG1024 | IGF1R | RTK | 5899.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0165 | 0.0780 | 0.7056 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9158.001 | uM | inf | inf | -0.9965 | -0.9965 | 0.0000 | 0.3194 | 0.2618 | 0.6988 | |
| 600MPE | HR+ | Luminal | Dichloroacetate | PDK | PDK | 13091.176 | uM | inf | inf | 0.9717 | 0.9717 | 0.0000 | 0.0439 | -0.10 | 0.8746 | |
| BT-20 | TNBC | Basal A | Trastuzumab | HER2 | ErbB | 5903.102 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0171 | -0.1575 | 1.2557 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 12224.072 | uM | inf | inf | 0.8349 | 0.8349 | 0.0000 | 0.1299 | -0.0188 | 1.0105 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7794.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.6812 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 5904.098 | uM | inf | inf | 0.8819 | 0.8819 | 0.0000 | 0.0368 | 0.3491 | 1.3264 | |
| 600MPE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 12224.157 | uM | inf | inf | 0.6710 | 0.6710 | 0.0000 | 0.1152 | 0.3373 | 1.0737 | |
| 600MPE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9118.001 | uM | inf | inf | 0.5960 | 0.5960 | 0.0000 | 0.1146 | 0.4985 | 1.0946 | |
| 600MPE | HR+ | Luminal | GW-5074 | CRAF | MAPK | 5898.088 | uM | inf | inf | 0.8157 | 0.8157 | 0.0000 | 0.0414 | -0.0040 | 0.6095 | |
| BT-474 | HER2amp | Luminal | PD184352 | MEK | MAPK | 12056.155 | uM | inf | inf | 0.5832 | 0.5832 | 0.0000 | 0.2074 | 0.1106 | 0.8251 | |
| HCC1187 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7811.018 | uM | inf | inf | 0.6946 | 0.6946 | 0.0000 | 0.1308 | -0.0060 | 0.4694 | |
| HCC1187 | TNBC | Basal A | Celecoxib | COX2 | COX | 10518.136 | uM | inf | inf | 0.9091 | 0.9091 | 0.0000 | 0.0220 | 0.1805 | 1.2490 |