Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Dichloroacetate | PDK | PDK | 12657.176 | uM | inf | inf | 0.9410 | 0.9410 | 0.0000 | 0.0143 | 0.5190 | 1.0711 | |
| LY2 | HR+ | Luminal | PD184352 | MEK | MAPK | 12319.155 | uM | inf | inf | 0.7640 | 0.7640 | 0.0000 | 0.0144 | 0.5546 | 0.9333 | |
| LY2 | HR+ | Luminal | PD184352 | MEK | MAPK | 12319.155 | uM | inf | inf | 0.7640 | 0.7640 | 0.0000 | 0.0144 | 0.5546 | 0.9333 | |
| MDA-MB-453 | TNBC | Luminal | Ribavirin | 15398.211 | uM | inf | inf | 0.8982 | 0.8982 | 0.0000 | 0.0145 | 0.1417 | 1.0628 | |||
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 10643.072 | uM | 139.8590 | 163.75380 | 0.1605 | -0.6002 | 4.9999 | 0.0146 | 0.9776 | 0.6128 | |
| T47DKBLUC | Unknown | Unknown | JNK-IN-5A | JNK | JNK | 12608.168 | uM | inf | inf | 0.9658 | 0.9658 | 0.0000 | 0.0146 | 0.0000 | 1.0486 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7505.05 | uM | 21.94740 | 24.13160 | 0.8214 | -0.3035 | 4.9994 | 0.0147 | 0.6601 | 0.9037 | |
| SUM1315MO2 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 10875.154 | uM | 32.91020 | 9.61220 | 0.4999 | 0.4988 | 4.8953 | 0.0149 | 0.9436 | 0.7163 | |
| AU565 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 13030.176 | uM | inf | inf | 0.8188 | 0.8188 | 0.0000 | 0.0150 | 0.5497 | 0.9892 | |
| AU565 | HER2amp | Luminal | Ribavirin | 15384.211 | uM | inf | 16.10260 | 0.6064 | 0.6043 | 4.5946 | 0.0152 | 0.9411 | 1.3162 | |||
| MDA-MB-361 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 10643.137 | uM | inf | 6.50940 | 0.7332 | 0.7331 | 4.9998 | 0.0153 | 0.7892 | 0.6468 | |
| ZR75B | HR+ | Luminal | PS-1145 | IKK | NFKB | 7555.065 | uM | inf | inf | 1.0207 | 1.0207 | 0.0000 | 0.0155 | 0.0000 | 1.7561 | |
| ZR75B | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7555.098 | uM | inf | inf | 0.9380 | 0.9380 | 0.0000 | 0.0155 | 0.0592 | 1.6495 | |
| MCF7 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9583.026 | uM | inf | inf | 0.9966 | 0.9966 | 0.0000 | 0.0156 | -0.0344 | 1.2731 | |
| SK-BR-3 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 11851.154 | uM | inf | inf | 0.9971 | 0.9971 | 0.0000 | 0.0156 | 0.0000 | 1.1765 | |
| HCC1395 | TNBC | Basal B | PS-1145 | IKK | NFKB | 7436.065 | uM | inf | 334.83990 | 0.7935 | 0.7935 | 5.0000 | 0.0156 | 0.8959 | 1.2177 | |
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 7907.043 | uM | inf | inf | 0.8215 | 0.8215 | 0.0000 | 0.0156 | 0.4868 | 1.6330 | |
| 184B5 | NM | Basal | JNK-IN-5A | JNK | JNK | 12566.168 | uM | 197.47390 | 224.21850 | 0.4789 | -0.4434 | 4.9982 | 0.0157 | 0.9558 | 1.4366 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 7456.073 | uM | 128.7210 | 98.23510 | 0.3989 | 0.2947 | 3.2924 | 0.0159 | 0.9731 | 1.8650 | |
| HCC1187 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7811.044 | uM | inf | inf | 0.9811 | 0.9811 | 0.0000 | 0.0159 | -0.0256 | 0.3073 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 7466.066 | uM | 42.15690 | 43.02170 | 0.1633 | -0.0345 | 3.2879 | 0.0160 | 0.9771 | 0.9420 | |
| MDA-MB-157 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7878.016 | uM | inf | 15.01940 | 0.7927 | 0.8386 | 4.9792 | 0.0160 | 0.7114 | 1.4153 | ||
| HCC1187 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7432.095 | uM | inf | inf | 1.0222 | 1.0222 | 0.0000 | 0.0161 | 0.1254 | 0.8368 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10643.146 | uM | inf | inf | 0.7735 | 0.7735 | 0.0000 | 0.0162 | 0.1132 | 0.6436 | |
| SUM149PT | TNBC | Basal B | Nilotinib | ABL | nRTK | 10819.145 | uM | inf | inf | 0.9866 | 0.9866 | 0.0000 | 0.0162 | 0.0826 | 2.1971 |