Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | FR180204 | ERK1/2 | MAPK | 11056.149 | uM | 49.1670 | 47.38650 | 0.8659 | 0.0842 | 4.9997 | 0.0119 | 0.6025 | 2.9204 | |
| HCC1395 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7814.042 | uM | 1.1580 | 1.97410 | 0.7528 | -0.7381 | 1.6997 | 0.0120 | 0.7787 | 0.8414 | |
| ZR75B | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7555.091 | uM | 222.88850 | 687.59880 | 0.7916 | -0.8665 | 0.8924 | 0.0120 | 0.8409 | 1.6040 | |
| HCC70 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7856.018 | uM | inf | inf | 0.8811 | 0.8811 | 0.0000 | 0.0121 | 0.4683 | 0.9388 | |
| MDA-MB-231 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7892.018 | uM | inf | 0.5010 | 0.8331 | 0.7197 | 1.2256 | 0.0122 | 0.8070 | 2.4903 | |
| BT-549 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 9024.016 | uM | inf | 5.49290 | 0.9158 | 0.9125 | 0.9479 | 0.0127 | 0.6896 | 3.2430 | ||
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7498.067 | uM | inf | 284.49690 | 0.8398 | 0.5893 | 0.8420 | 0.0128 | 0.7609 | 1.1346 | |
| HCC38 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7469.066 | uM | inf | inf | 0.9727 | 0.9727 | 0.0000 | 0.0128 | -0.0529 | 2.0057 | |
| MB 157 | Unknown | Unknown | PD 98059 | MEK | MAPK | 12580.152 | uM | inf | 13.27340 | 0.8145 | 0.8142 | 4.7549 | 0.0130 | 0.9491 | 2.2597 | |
| HCC1395 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7436.095 | uM | inf | inf | 0.9643 | 0.9643 | 0.0000 | 0.0131 | 0.0000 | 1.3597 | |
| HCC1937 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 13115.176 | uM | inf | 0.22160 | 0.8209 | 0.8738 | 5.0000 | 0.0131 | 0.6538 | 0.8197 | |
| BT-549 | TNBC | Basal B | L-779450 | BRAF | MAPK | 12305.166 | uM | 50.02890 | 43.34140 | 0.8426 | 0.2560 | 4.9997 | 0.0132 | 0.6646 | 2.9556 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7498.098 | uM | inf | 22.53420 | 0.8724 | 0.7240 | 0.6002 | 0.0132 | 0.6801 | 1.1057 | |
| MCF 10F | NM | - | Ribavirin | 15393.211 | uM | inf | inf | 0.8354 | 0.8354 | 0.0000 | 0.0133 | 0.5287 | 1.6449 | |||
| MDA-MB-415 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 7511.073 | uM | inf | 52.84510 | 0.6306 | 0.6292 | 4.8844 | 0.0134 | 0.9407 | 1.0909 | |
| ZR75B | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9972.125 | uM | 4.30080 | 14.18760 | 0.8594 | -0.8482 | 0.8310 | 0.0135 | 0.6892 | 1.1854 | |
| HCC3153 | TNBC | Basal A | Nilotinib | ABL | nRTK | 10937.145 | uM | inf | inf | 1.0433 | 1.0433 | 0.0000 | 0.0136 | 0.0664 | 1.2098 | |
| SUM159PT | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7531.067 | uM | inf | 34.52310 | 0.8619 | 0.8619 | 5.0000 | 0.0137 | 0.8457 | 3.6061 | |
| 184B5 | NM | Basal | Cisplatin | DNA cross-linker | DNA cross-linker | 9095.049 | uM | inf | 193.58440 | 0.7160 | 0.7080 | 3.7384 | 0.0137 | 0.8937 | 1.1202 | |
| T47DKBLUC | Unknown | Unknown | Erlotinib | EGFR | ErbB | 7544.092 | uM | inf | inf | 0.9208 | 0.9208 | 0.0000 | 0.0137 | -0.0102 | 1.1147 | |
| SK-BR-3 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7526.066 | uM | 165.54090 | 435.63610 | 0.8376 | -0.6562 | 0.8664 | 0.0138 | 0.850 | 1.5937 | |
| MCF7 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7492.095 | uM | inf | inf | 0.9180 | 0.9180 | 0.0000 | 0.0139 | 0.0229 | 1.0194 | |
| T47DKBLUC | Unknown | Unknown | Nelfinavir | 13070.174 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0140 | 0.0000 | 0.7993 | |||
| MB 157 | Unknown | Unknown | PS-1145 | IKK | NFKB | 7482.065 | uM | inf | inf | 0.9413 | 0.9413 | 0.0000 | 0.0141 | 0.0523 | 2.2390 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 10577.137 | uM | 128.91780 | 407.61850 | 0.8182 | -0.9196 | 0.9065 | 0.0143 | 0.7373 | 0.9653 |