Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 9042.05 | uM | inf | 0.00489 | 0.5173 | 0.4903 | 0.2989 | 0.3056 | 0.8755 | 3.1161 | |
| HCC1187 | TNBC | Basal A | LY294002 | PI3K | PI3K | 7812.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0475 | -56.7271 | 0.9642 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 7920.05 | uM | inf | 0.02034 | 0.4715 | 0.5077 | 0.6584 | 0.2518 | 0.9823 | 4.1624 | |
| MCF 10A | NM | Basal B | Ribavirin | 15392.211 | uM | inf | 1000.00000 | 0.6244 | 0.0123 | 0.2385 | 0.1289 | 0.6395 | 2.9667 | |||
| MDA-MB-175-VII | HR+ | Luminal | PS-1145 | IKK | NFKB | 7500.065 | uM | inf | inf | 0.5879 | 0.5879 | 0.0000 | 0.1172 | 0.4159 | 0.8201 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7432.084 | uM | inf | 0.04650 | 0.7826 | 0.8570 | 4.9898 | 0.0847 | 0.6431 | 0.8538 | |
| BT-20 | TNBC | Basal A | Ribavirin | 15385.211 | uM | inf | inf | 0.4315 | 0.4315 | 0.0000 | 0.1628 | 0.4682 | 0.7321 | |||
| HCC1143 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14203.189 | uM | inf | inf | 0.2602 | 0.2602 | 0.0000 | 0.4744 | 0.4731 | 1.6955 | |
| MDA-MB-175-VII | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10818.144 | uM | inf | inf | 0.8824 | 0.8824 | 0.0000 | 0.1129 | 0.2209 | 0.4912 | |
| MDA-MB-157 | TNBC | Basal B | SB-3CT | MMP2/9 | MMP | 12594.168 | uM | inf | 22.51110 | 0.8515 | 0.8506 | 2.5343 | 0.0205 | 0.7536 | 1.2703 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 7477.066 | uM | inf | inf | 0.2846 | 0.2846 | 0.0000 | 0.3601 | 0.3237 | 0.3409 | |
| HCC2185 | TNBC | Luminal | JNK-IN-5A | JNK | JNK | 10996.144 | uM | inf | inf | 0.3659 | 0.3659 | 0.0000 | 0.2133 | 0.3780 | 0.5116 | |
| HCC1806 | TNBC | Basal A | Nilotinib | ABL | nRTK | 12239.145 | uM | inf | inf | 0.9597 | 0.9597 | 0.0000 | 0.0201 | -0.0222 | 2.1348 | |
| MCF 10F | NM | - | PS-1145 | IKK | NFKB | 7486.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0198 | -0.3050 | 1.1517 | |
| BT-20 | TNBC | Basal A | Selumetinib | MEK | MAPK | 11854.155 | uM | inf | inf | 0.9135 | 0.9135 | 0.0000 | 0.0714 | 0.3056 | 1.3396 | |
| MCF 10F | NM | - | FTase Inhibitor I | Ftase | MAPK | 12254.154 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0451 | -13.9008 | 1.6307 | |
| MDA-MB-157 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7882.016 | uM | inf | inf | 0.7087 | 0.7087 | 0.0000 | 0.1209 | 0.5649 | 1.0905 | ||
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 7472.066 | uM | inf | inf | 0.9265 | 0.9265 | 0.0000 | -0.0306 | 0.0660 | 1.8363 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7493.067 | uM | inf | inf | 0.9222 | 0.9222 | 0.0000 | 0.0803 | 0.0000 | 1.3684 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 11057.15 | uM | inf | 0.43340 | 0.6315 | 0.6227 | 5.0000 | 0.1138 | 0.9875 | 4.0042 | |
| MCF 10F | NM | - | 5-FU | TYMS | TYMS | 7872.017 | uM | inf | inf | 1.0126 | 1.0126 | 0.0000 | 0.1656 | 0.1751 | 1.5155 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 7807.017 | uM | inf | inf | -0.4695 | -0.4695 | 0.0000 | 0.2218 | 0.4545 | 2.2007 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9163.011 | uM | inf | 0.03578 | 0.4237 | 0.5176 | 5.0000 | 0.3079 | 0.9295 | 0.6266 | |
| BT-20 | TNBC | Basal A | PS-1145 | IKK | NFKB | 10385.065 | uM | inf | inf | 0.4664 | 0.4664 | 0.0000 | 0.3016 | 0.3040 | 0.6599 | |
| HCC70 | TNBC | Basal A | Nilotinib | ABL | nRTK | 12400.17 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0014 | -0.0040 | 1.1992 |