Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Docetaxel | TUBB | TUBB | 7918.002 | uM | 0.00859 | 0.01002 | -0.0723 | -0.1259 | 1.4569 | 0.5958 | 0.9893 | 2.8377 | |
| 184B5 | NM | Basal | Geldanamycin | HSP90 | HSP90 | 9095.049 | uM | 0.00859 | 0.01158 | -0.7576 | -0.7255 | 2.9985 | 1.2019 | 0.9991 | 1.1202 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 9386.001 | uM | 0.00862 | 0.01038 | -0.6745 | -0.4278 | 3.3304 | 0.8885 | 0.9609 | 1.3243 | |
| MDA-MB-453 | TNBC | Luminal | Taxol | TUBB | TUBB | 12964.002 | uM | 0.00864 | 0.01139 | -0.5617 | -0.5234 | 2.5980 | 0.9297 | 0.9952 | 0.5925 | |
| BT-474 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9158.002 | uM | 0.00864 | 0.01271 | -0.8158 | -0.7150 | 2.3051 | 1.0217 | 0.9943 | 0.4298 | |
| MDA-MB-134-VI | HR+ | Luminal | Topotecan | TOP1 | TOP | 7877.007 | uM | 0.00865 | 0.07627 | -0.8458 | -0.9029 | 0.4739 | 1.0580 | 0.9853 | 0.5977 | |
| BT-474 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 12178.158 | uM | 0.00866 | 0.02277 | -0.9958 | -0.8611 | 1.0356 | 1.1447 | 0.9876 | 0.7379 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 9844.012 | uM | 0.00867 | 0.00452 | 0.2050 | 0.2849 | 1.2949 | 0.4496 | 0.9866 | 2.2776 | |
| SUM149PT | TNBC | Basal B | Taxol | TUBB | TUBB | 9830.002 | uM | 0.00867 | 0.00909 | -0.1990 | -0.1346 | 4.9998 | 0.7185 | 0.9873 | 1.9252 | |
| JIMT-1 | HER2amp | Basal | Torkinib | 15353.211 | uM | 0.00868 | 0.06497 | -0.4055 | -0.5247 | 0.3564 | 0.7826 | 0.9963 | 2.0011 | |||
| BT-549 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9024.018 | uM | 0.00869 | 0.01108 | -0.6646 | -0.2963 | 1.9145 | 0.8159 | 0.9381 | 2.8306 | |
| SUM52PE | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9878.012 | uM | 0.00869 | 0.01198 | -0.3961 | -0.3029 | 1.4774 | 0.9011 | 0.9907 | 1.2431 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 7816.007 | uM | 0.00871 | 0.04726 | -0.6908 | -0.6747 | 0.5051 | 0.9894 | 0.9549 | 1.1536 | |
| MX1 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 14918.203 | uM | 0.00872 | 0.01466 | -0.9994 | -0.9980 | 2.1115 | 1.3233 | 0.9984 | 0.5296 | |
| MX1 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 14918.203 | uM | 0.00872 | 0.01466 | -0.9994 | -0.9980 | 2.1115 | 1.3233 | 0.9984 | 0.5296 | |
| HCC1187 | TNBC | Basal A | GSK1070916 | AURK | AURK | 9244.001 | uM | 0.00874 | 0.01067 | -0.8996 | -0.8591 | 5.0000 | 1.1518 | 0.9961 | 0.5421 | |
| HCC2185 | TNBC | Luminal | Taxol | TUBB | TUBB | 7849.002 | uM | 0.00876 | 0.00931 | -0.1459 | -0.1763 | 4.9996 | 0.7465 | 0.9941 | 0.5525 | |
| UACC-812 | HER2amp | Luminal | Taxol | TUBB | TUBB | 13078.002 | uM | 0.00883 | 0.00969 | -0.3363 | -0.2963 | 4.9971 | 0.8286 | 0.9937 | 0.6437 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 7491.078 | uM | 0.00884 | 0.07326 | -0.9966 | -1.0000 | 0.5196 | 1.1630 | 0.9783 | 0.7238 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 7896.011 | uM | 0.00886 | 0.00925 | -0.0646 | -0.0360 | 1.6164 | 0.7726 | 0.9953 | 1.0906 | |
| HCC38 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9028.018 | uM | 0.00890 | 0.01030 | -0.9593 | -0.5379 | 4.9999 | 1.0110 | 0.9456 | 1.0242 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9953.001 | uM | 0.00892 | 0.00997 | -0.6091 | -0.3691 | 5.0000 | 0.8976 | 0.9020 | 0.3377 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 7517.086 | uM | 0.00895 | 0.04675 | -0.9208 | -0.8781 | 0.6134 | 0.9551 | 0.9920 | 1.4126 | |
| MDA-MB-415 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7897.018 | uM | 0.0090 | 0.78301 | -0.9931 | -1.0000 | 0.2460 | 0.7416 | 0.7145 | 0.8448 | |
| SUM149PT | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7530.095 | uM | 0.00902 | 0.13037 | -0.7859 | -0.9204 | 0.3909 | 0.8505 | 0.9144 | 2.2670 |