Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Docetaxel | TUBB | TUBB | 9860.002 | uM | 0.00390 | 0.00430 | -0.1347 | -0.1014 | 1.9159 | 0.6524 | 0.9980 | 1.5734 | |
| HCC1428 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15304.203 | uM | 0.00390 | 0.00809 | -0.8712 | -0.7326 | 1.2363 | 1.2126 | 0.9549 | 0.7449 | |
| HCC1428 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15304.203 | uM | 0.00390 | 0.00809 | -0.8712 | -0.7326 | 1.2363 | 1.2126 | 0.9549 | 0.7449 | |
| MDA-MB-361 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 12379.164 | uM | 0.00391 | 0.03155 | -0.8811 | -0.7211 | 0.4276 | 0.9830 | 0.9557 | 0.4318 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 11660.144 | uM | 0.00395 | 1.80850 | -0.9804 | -1.0000 | 0.1793 | 0.8085 | 0.6199 | 1.0279 | |
| HCC3153 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7467.095 | uM | 0.0040 | 0.00623 | -0.9545 | -0.5226 | 1.6137 | 1.0115 | 0.9385 | 1.2671 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 7791.05 | uM | 0.00402 | 0.00304 | 0.0608 | 0.1734 | 1.5319 | 0.5504 | 0.9742 | 0.7929 | |
| SUM225CWN | HER2amp | Basal A | Sirolimus | MTOR | MTOR | 7533.069 | uM | 0.00404 | 0.00166 | 0.2934 | 0.3132 | 1.1071 | 0.5248 | 0.9943 | 1.1713 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14924.203 | uM | 0.00405 | 0.00616 | -0.9568 | -0.9655 | 2.5587 | 1.4202 | 0.9993 | 1.0024 | |
| UACC-812 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 10420.095 | uM | 0.00405 | 0.00426 | -0.9993 | -0.0422 | 1.5655 | 0.6669 | 0.5965 | 0.5783 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14924.203 | uM | 0.00405 | 0.00616 | -0.9568 | -0.9655 | 2.5587 | 1.4202 | 0.9993 | 1.0024 | |
| Hs 578T | TNBC | Basal B | Taxol | TUBB | TUBB | 9511.002 | uM | 0.00407 | 0.00628 | -0.6889 | -0.5691 | 1.7559 | 1.0292 | 0.9934 | 1.1960 | |
| UACC-812 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 10267.002 | uM | 0.00408 | 0.00445 | -0.2526 | -0.2764 | 5.0000 | 0.7526 | 0.9798 | 0.4069 | |
| Hs 578T | TNBC | Basal B | Taxol | TUBB | TUBB | 7864.002 | uM | 0.00409 | 0.00803 | -0.5125 | -0.4792 | 0.9967 | 0.9577 | 0.9913 | 1.5910 | |
| MDA-MB-453 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 9708.002 | uM | 0.00410 | 0.00517 | -0.2719 | -0.2112 | 1.5193 | 0.7165 | 0.9926 | 1.0482 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7856.001 | uM | 0.00410 | 0.00442 | -0.4520 | -0.2286 | 5.0000 | 0.8187 | 0.9277 | 0.7111 | |
| HCC1143 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7810.002 | uM | 0.00412 | 0.00608 | -0.2888 | -0.2655 | 1.0948 | 0.7382 | 0.9669 | 1.1625 | |
| SUM52PE | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14811.203 | uM | 0.00412 | 0.01039 | -0.5052 | -0.4361 | 0.6785 | 0.9522 | 0.9623 | 1.0107 | |
| SUM52PE | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14811.203 | uM | 0.00412 | 0.01039 | -0.5052 | -0.4361 | 0.6785 | 0.9522 | 0.9623 | 1.0107 | |
| HCC1187 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7432.069 | uM | 0.00413 | 0.00589 | -0.2280 | -0.1078 | 0.5477 | 0.7176 | 0.9579 | 0.9727 | |
| SUM149PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7917.001 | uM | 0.00415 | 0.00405 | -0.0990 | 0.0224 | 1.8466 | 0.6785 | 0.9685 | 2.9486 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9536.002 | uM | 0.00418 | 0.00548 | -0.2397 | -0.2457 | 1.4695 | 0.7191 | 0.9989 | 1.3627 | |
| MDA-MB-134-VI | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7877.042 | uM | 0.00423 | 0.00521 | -0.9988 | -0.7895 | 4.5360 | 1.2744 | 0.9640 | 0.3414 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 10263.001 | uM | 0.00423 | 0.00507 | -0.9767 | -0.7367 | 5.0000 | 1.1583 | 0.9733 | 0.3258 | |
| SUM1315MO2 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9797.006 | uM | 0.00425 | 0.00528 | -1.0000 | -0.9693 | 4.9995 | 1.7533 | 0.9968 | 0.4196 |