Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7905.018 | uM | 0.00355 | 0.00425 | -0.8287 | -0.7200 | 5.0000 | 1.2755 | 0.9033 | 0.8988 | |
| HCC38 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7468.095 | uM | 0.00356 | 0.00561 | -0.9857 | -0.5908 | 1.7194 | 1.0633 | 0.9517 | 1.4474 | |
| T47D | HR+ | Luminal | Omipalisib | PI3K | PI3K | 7542.086 | uM | 0.00360 | 0.00826 | -0.6357 | -0.5070 | 0.8440 | 0.9489 | 0.9855 | 1.0375 | |
| 184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 9047.026 | uM | 0.00360 | 0.01403 | -0.2605 | -0.4617 | 0.4805 | 0.4918 | 0.8777 | 0.5972 | |
| HCC1419 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7818.068 | uM | 0.00361 | 0.00461 | -0.2968 | -0.0865 | 0.6554 | 0.8440 | 0.9116 | 0.7038 | |
| HCC1143 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14829.203 | uM | 0.00363 | 0.01223 | -0.9240 | -0.9232 | 0.8622 | 1.2815 | 0.9991 | 1.2743 | |
| MDA-MB-453 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 7903.002 | uM | 0.00363 | 0.00472 | -0.4272 | -0.4291 | 2.3694 | 0.8593 | 0.9957 | 1.2202 | |
| HCC1143 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14829.203 | uM | 0.00363 | 0.01223 | -0.9240 | -0.9232 | 0.8622 | 1.2815 | 0.9991 | 1.2743 | |
| HCC1419 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 12001.165 | uM | 0.00364 | 0.01397 | -0.9997 | -0.9330 | 0.7834 | 1.2629 | 0.9922 | 0.5382 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 14807.203 | uM | 0.00365 | 0.00535 | -0.7798 | -0.7104 | 2.3037 | 1.2491 | 0.9925 | 1.7148 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 14807.203 | uM | 0.00365 | 0.00535 | -0.7798 | -0.7104 | 2.3037 | 1.2491 | 0.9925 | 1.7148 | |
| UACC-812 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9913.002 | uM | 0.00368 | 0.00315 | 0.2367 | 0.1420 | 2.1296 | 0.5464 | 0.9437 | 0.6723 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9648.011 | uM | 0.00368 | 0.00618 | -0.5201 | -0.5019 | 1.3387 | 1.1674 | 0.9957 | 0.6920 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15340.203 | uM | 0.00373 | 0.00642 | -0.9095 | -0.9143 | 1.9126 | 1.3715 | 0.9998 | 1.4449 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15340.203 | uM | 0.00373 | 0.00642 | -0.9095 | -0.9143 | 1.9126 | 1.3715 | 0.9998 | 1.4449 | |
| MDA-MB-361 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 10095.002 | uM | 0.00373 | 0.00429 | -0.0736 | -0.1027 | 1.3348 | 0.6771 | 0.9570 | 0.9451 | |
| HCC2185 | TNBC | Luminal | Temsirolimus | MTOR | MTOR | 10996.144 | uM | 0.00375 | 0.18883 | -0.9997 | -1.0000 | 0.2804 | 0.9938 | 0.8849 | 0.5116 | |
| SUM149PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 15330.203 | uM | 0.00376 | 0.00649 | -0.8564 | -0.7184 | 1.6353 | 1.2319 | 0.9909 | 1.2836 | |
| SUM149PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 15330.203 | uM | 0.00376 | 0.00649 | -0.8564 | -0.7184 | 1.6353 | 1.2319 | 0.9909 | 1.2836 | |
| EFM-19 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15296.203 | uM | 0.00378 | 0.00648 | -0.9285 | -0.9001 | 1.9073 | 1.3477 | 0.9972 | 1.1208 | |
| EFM-19 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15296.203 | uM | 0.00378 | 0.00648 | -0.9285 | -0.9001 | 1.9073 | 1.3477 | 0.9972 | 1.1208 | |
| MDA-MB-415 | HR+ | Luminal | Taxol | TUBB | TUBB | 9664.002 | uM | 0.00381 | 0.00666 | -0.4486 | -0.4175 | 1.0850 | 0.9491 | 0.9767 | 0.5947 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 7454.087 | uM | 0.00381 | 0.01412 | -0.8082 | -0.8406 | 0.7530 | 1.1374 | 0.9564 | 1.2157 | |
| HCC2185 | TNBC | Luminal | Temsirolimus | MTOR | MTOR | 12192.144 | uM | 0.00382 | 0.03008 | -0.8304 | -0.5780 | 0.3722 | 0.9625 | 0.8793 | 0.5798 | |
| SUM159PT | TNBC | Basal B | Taxol | TUBB | TUBB | 13054.002 | uM | 0.00389 | 0.00463 | -0.1850 | -0.1586 | 1.5931 | 0.8001 | 0.9981 | 3.0574 |