Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7818.05 | uM | 6.20090 | 0.00082 | 0.3938 | 0.4924 | 0.4692 | 0.3679 | 0.6443 | 0.9274 | |
| HMT-3522 T4-2 | Unknown | Unknown | Trametinib | MEK | MAPK | 10147.012 | uM | 0.00098 | 0.00091 | -0.1956 | 0.0632 | 1.9761 | 0.7030 | 0.8821 | 1.6544 | |
| EFM-19 | HR+ | Luminal | Torkinib | 15296.211 | uM | 0.00003 | 0.00091 | -0.4760 | -0.5739 | 0.2205 | 1.1055 | 0.9560 | 1.4068 | |||
| SUM159PT | TNBC | Basal B | Docetaxel | TUBB | TUBB | 13054.002 | uM | 0.00080 | 0.00091 | -0.1135 | -0.1113 | 1.6186 | 0.8007 | 0.9974 | 3.0574 | |
| CAMA-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 5912.095 | uM | 0.00065 | 0.00095 | -0.9867 | -0.7402 | 2.3688 | 1.4206 | 0.9535 | 0.9981 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7879.001 | uM | 0.00096 | 0.00101 | -0.3010 | -0.0757 | 2.6224 | 0.8576 | 0.9447 | 1.8589 | |
| SUM52PE | HR+ | Luminal | Docetaxel | TUBB | TUBB | 12969.002 | uM | 0.00197 | 0.00104 | 0.1240 | 0.1207 | 0.4307 | 0.5928 | 0.7473 | 1.0653 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 12333.165 | uM | inf | 0.00107 | 0.6376 | 0.6596 | 4.9998 | 0.2729 | 0.7587 | 0.6207 | |
| SUM159PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7918.018 | uM | 0.00074 | 0.00109 | -0.5523 | -0.3456 | 1.3735 | 1.1044 | 0.9653 | 3.0213 | |
| HCC1954 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 7835.018 | uM | 0.00137 | 0.00114 | 0.1067 | 0.3017 | 5.0000 | 0.3251 | 0.8954 | 0.5326 | |
| MDA-MB-453 | TNBC | Luminal | Trastuzumab | HER2 | ErbB | 9723.124 | uM | inf | 0.00115 | 0.4864 | 0.6553 | 4.9994 | 0.2269 | 0.8119 | 0.9827 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 7849.001 | uM | 0.00104 | 0.00115 | -0.9115 | -0.3518 | 5.0000 | 1.0464 | 0.8751 | 0.5308 | |
| HBL-100 | Unknown | Unknown | Docetaxel | TUBB | TUBB | 9226.002 | uM | 0.00159 | 0.00118 | 0.3255 | 0.2348 | 2.1218 | 0.5458 | 0.9405 | 2.4245 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7909.001 | uM | 0.00120 | 0.00121 | 0.2096 | -0.0127 | 5.0000 | 0.8306 | 0.6530 | 1.5909 | |
| MDA-MB-415 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7510.068 | uM | 0.00143 | 0.00123 | 0.0726 | 0.0555 | 0.7570 | 0.8274 | 0.9007 | 0.7539 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7896.001 | uM | 0.00127 | 0.00125 | -0.1757 | 0.0463 | 5.0000 | 0.7450 | 0.9286 | 1.1912 | |
| AU565 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 13030.002 | uM | 0.00092 | 0.00128 | -0.9104 | -0.8772 | 3.0709 | 1.3116 | 0.9975 | 0.5732 | |
| MDA-MB-361 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7508.095 | uM | 0.00087 | 0.00130 | -0.9942 | -0.6037 | 1.9635 | 1.2595 | 0.9267 | 0.7473 | |
| HCC2185 | TNBC | Luminal | Torkinib | 15306.211 | uM | 0.00017 | 0.00130 | -0.8220 | -0.8191 | 0.4777 | 1.4061 | 0.9962 | 0.4935 | |||
| HCC1187 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7432.095 | uM | 0.00090 | 0.00136 | -0.9922 | -0.9565 | 2.5808 | 1.5603 | 0.9988 | 0.8368 | |
| HCC70 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7857.042 | uM | inf | 0.00139 | 0.7456 | 0.7944 | 5.0000 | 0.1040 | 0.8457 | 1.1910 | |
| HCC38 | TNBC | Basal B | Torkinib | 15351.211 | uM | 0.00026 | 0.00145 | -0.9254 | -0.8879 | 0.5960 | 1.4733 | 0.9779 | 1.0866 | |||
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14739.203 | uM | 0.00093 | 0.00145 | -0.9973 | -0.9997 | 2.4844 | 1.6705 | 0.9952 | 0.6862 | |
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14739.203 | uM | 0.00093 | 0.00145 | -0.9973 | -0.9997 | 2.4844 | 1.6705 | 0.9952 | 0.6862 | |
| HCC2185 | TNBC | Luminal | Sirolimus | MTOR | MTOR | 7464.069 | uM | 0.00147 | 0.00146 | -0.1430 | 0.0071 | 2.1945 | 0.7708 | 0.9675 | 0.6495 |