Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7432.069 | uM | 0.00413 | 0.00589 | -0.2280 | -0.1078 | 0.5477 | 0.7176 | 0.9579 | 0.9727 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 10093.001 | uM | 0.00477 | 0.00590 | -0.9996 | -0.9361 | 5.0000 | 1.3152 | 0.9914 | 0.5759 | |
| MDA-MB-175-VII | HR+ | Luminal | Docetaxel | TUBB | TUBB | 7886.002 | uM | 0.01312 | 0.00590 | 0.3827 | 0.3533 | 1.5335 | 0.3606 | 0.9836 | 0.7173 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7820.05 | uM | 0.01530 | 0.00593 | 0.2545 | 0.3401 | 1.2031 | 0.4101 | 0.8544 | 0.4219 | |
| HBL-100 | Unknown | Unknown | Taxol | TUBB | TUBB | 7808.002 | uM | 0.00567 | 0.00596 | -0.0881 | -0.0331 | 1.2754 | 0.6816 | 0.9935 | 2.3302 | |
| SUM149PT | TNBC | Basal B | Trametinib | MEK | MAPK | 9830.012 | uM | 0.01431 | 0.00599 | 0.2532 | 0.2704 | 0.8936 | 0.4424 | 0.9907 | 1.8343 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9878.001 | uM | 0.00532 | 0.00606 | -0.2712 | -0.1337 | 1.8195 | 0.7604 | 0.9501 | 1.3386 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 7919.036 | uM | 0.38794 | 0.00606 | 0.4640 | 0.4828 | 0.8106 | 0.3207 | 0.9910 | 3.6233 | |
| HCC1143 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7810.002 | uM | 0.00412 | 0.00608 | -0.2888 | -0.2655 | 1.0948 | 0.7382 | 0.9669 | 1.1625 | |
| ZR75B | HR+ | Luminal | Taxol | TUBB | TUBB | 9972.002 | uM | 0.00755 | 0.00610 | 0.1087 | 0.1821 | 2.1270 | 0.5439 | 0.9847 | 1.0054 | |
| MDA-MB-468 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7907.018 | uM | 0.00547 | 0.00613 | -0.5052 | -0.3801 | 4.9982 | 0.9722 | 0.9248 | 1.5217 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14924.203 | uM | 0.00405 | 0.00616 | -0.9568 | -0.9655 | 2.5587 | 1.4202 | 0.9993 | 1.0024 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7793.018 | uM | 0.00513 | 0.00616 | -0.8816 | -0.7443 | 4.9977 | 1.1997 | 0.990 | 1.3186 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14924.203 | uM | 0.00405 | 0.00616 | -0.9568 | -0.9655 | 2.5587 | 1.4202 | 0.9993 | 1.0024 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9648.011 | uM | 0.00368 | 0.00618 | -0.5201 | -0.5019 | 1.3387 | 1.1674 | 0.9957 | 0.6920 | |
| SUM52PE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 7539.087 | uM | 0.00346 | 0.00619 | -0.4621 | -0.3727 | 0.9570 | 0.9127 | 0.9908 | 1.2155 | |
| HCC3153 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7467.095 | uM | 0.0040 | 0.00623 | -0.9545 | -0.5226 | 1.6137 | 1.0115 | 0.9385 | 1.2671 | |
| MDA-MB-415 | HR+ | Luminal | Taxol | TUBB | TUBB | 7897.002 | uM | 0.00585 | 0.00625 | -0.0901 | -0.0289 | 0.8488 | 0.6826 | 0.9759 | 0.8381 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7907.001 | uM | 0.00479 | 0.00628 | -0.3488 | -0.3455 | 1.9422 | 0.8990 | 0.8321 | 1.3308 | |
| Hs 578T | TNBC | Basal B | Taxol | TUBB | TUBB | 9511.002 | uM | 0.00407 | 0.00628 | -0.6889 | -0.5691 | 1.7559 | 1.0292 | 0.9934 | 1.1960 | |
| HCC1954 | HER2amp | Basal A | Vinorelbine | TUBB | TUBB | 7836.018 | uM | 0.00486 | 0.00632 | -0.9706 | -0.5857 | 2.9407 | 1.1119 | 0.910 | 1.0819 | |
| BT-549 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 5910.069 | uM | inf | 0.00633 | 0.6831 | 0.7149 | 0.7161 | 0.1843 | 0.9657 | 3.3504 | |
| BT-474 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7798.068 | uM | inf | 0.00634 | 0.4293 | 0.5223 | 2.3948 | 0.3712 | 0.9582 | 1.2859 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 9551.012 | uM | 0.00733 | 0.00636 | 0.1316 | 0.1356 | 2.2386 | 0.5355 | 0.9963 | 2.7057 | |
| HCC1806 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7451.095 | uM | 0.00335 | 0.00636 | -0.8230 | -0.3798 | 0.8819 | 0.8966 | 0.8817 | 2.2028 |