Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7907.002 | uM | 0.00296 | 0.00490 | -0.5517 | -0.6130 | 1.5918 | 0.9737 | 0.9754 | 1.5984 | |
| SK-BR-3 | HER2amp | Luminal | Torkinib | 15356.211 | uM | 0.00125 | 0.00492 | -0.3826 | -0.3333 | 0.3720 | 0.8953 | 0.9717 | 1.3112 | |||
| HCC1187 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 12696.002 | uM | 0.00173 | 0.00493 | -0.9723 | -0.9900 | 1.0427 | 1.1646 | 0.9945 | 0.7184 | |
| MDA-MB-453 | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 7903.042 | uM | 0.00441 | 0.00494 | -0.9524 | -0.3548 | 4.7159 | 0.9002 | 0.8859 | 1.1508 | |
| HCC38 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7469.095 | uM | 0.00310 | 0.00497 | -0.9048 | -0.5016 | 1.4776 | 1.0099 | 0.9446 | 1.8946 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 7457.084 | uM | inf | 0.00498 | 0.4882 | 0.5245 | 5.0000 | 0.4044 | 0.8926 | 1.8520 | |
| ZR-75-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 12003.155 | uM | inf | 0.00501 | 0.8304 | 0.8464 | 0.5638 | 0.1047 | 0.6326 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 12003.155 | uM | inf | 0.00501 | 0.8304 | 0.8464 | 0.5638 | 0.1047 | 0.6326 | 1.1249 | |
| MCF 10F | NM | - | Sirolimus | MTOR | MTOR | 7488.068 | uM | inf | 0.00504 | 0.4498 | 0.5302 | 1.0402 | 0.3713 | 0.9434 | 1.3560 | |
| SUM1315MO2 | TNBC | Basal B | Taxol | TUBB | TUBB | 9797.002 | uM | 0.00284 | 0.00504 | -0.9455 | -0.9308 | 1.8346 | 1.3072 | 0.9984 | 0.4052 | |
| CAL-85-1 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15280.203 | uM | 0.00265 | 0.00507 | -0.9828 | -0.9851 | 1.6797 | 1.4734 | 0.9952 | 0.7211 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 10263.001 | uM | 0.00423 | 0.00507 | -0.9767 | -0.7367 | 5.0000 | 1.1583 | 0.9733 | 0.3258 | |
| CAL-85-1 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15280.203 | uM | 0.00265 | 0.00507 | -0.9828 | -0.9851 | 1.6797 | 1.4734 | 0.9952 | 0.7211 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 7886.011 | uM | 0.00562 | 0.00512 | -0.0228 | 0.0707 | 1.6531 | 0.7393 | 0.9469 | 0.6942 | |
| SUM159PT | TNBC | Basal B | Taxol | TUBB | TUBB | 13004.002 | uM | 0.00449 | 0.00513 | -0.1960 | -0.1508 | 1.9936 | 0.7840 | 0.9981 | 3.1387 | |
| BT-20 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 10385.095 | uM | 0.00319 | 0.00514 | -0.9980 | -0.5798 | 1.6199 | 1.0590 | 0.9374 | 0.7986 | |
| HCC1428 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9294.002 | uM | 0.01312 | 0.00515 | 0.3113 | 0.3127 | 1.0488 | 0.3931 | 0.9892 | 0.7467 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9035.018 | uM | 0.00465 | 0.00516 | -0.4202 | -0.3390 | 5.0000 | 0.9224 | 0.9868 | 2.1555 | |
| MDA-MB-453 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 9708.002 | uM | 0.00410 | 0.00517 | -0.2719 | -0.2112 | 1.5193 | 0.7165 | 0.9926 | 1.0482 | |
| MDA-MB-134-VI | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7877.042 | uM | 0.00423 | 0.00521 | -0.9988 | -0.7895 | 4.5360 | 1.2744 | 0.9640 | 0.3414 | |
| HCC1937 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 10262.002 | uM | 0.00534 | 0.00521 | 0.0885 | 0.0565 | 5.0000 | 0.5451 | 0.9835 | 0.6356 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9254.001 | uM | 0.00450 | 0.00522 | -1.0000 | -0.5435 | 5.0000 | 1.0717 | 0.8911 | 0.3986 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7803.04 | uM | 0.00496 | 0.00526 | -0.1497 | -0.1683 | 4.9432 | 0.9129 | 0.9968 | 2.8752 | |
| ZR-75-1 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 7932.002 | uM | 0.02764 | 0.00527 | 0.4929 | 0.4679 | 1.6551 | 0.2991 | 0.9428 | 0.8992 | |
| SUM1315MO2 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9797.006 | uM | 0.00425 | 0.00528 | -1.0000 | -0.9693 | 4.9995 | 1.7533 | 0.9968 | 0.4196 |