Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 21MT-1 | HER2amp | - | Mebendazole | 13719.174 | uM | 31.97060 | 77.55140 | 0.0875 | -1.0000 | 1.2398 | 0.1610 | 0.8782 | 0.8124 | |||
| 21MT-1 | HER2amp | - | Methylglyoxal | 13719.184 | uM | 680.32080 | 999.99990 | -0.9954 | -0.9645 | 2.7899 | 0.6345 | 0.9961 | 0.7600 | |||
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| 184A1 | NM | Basal | Vorinostat | HDAC | HDAC | 5895.065 | uM | 141.55360 | 735.01640 | -0.6699 | -0.8793 | 0.6160 | 0.4840 | 0.9909 | 1.3748 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14607.189 | uM | 0.09589 | 0.20341 | -0.9029 | -0.9017 | 1.3707 | 0.8886 | 0.9922 | 1.3733 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14607.189 | uM | 0.09589 | 0.20341 | -0.9029 | -0.9017 | 1.3707 | 0.8886 | 0.9922 | 1.3733 | |
| 184A1 | NM | Basal | Vorinostat | HDAC | HDAC | 5894.065 | uM | 174.64490 | 418.8430 | -0.3946 | -0.4684 | 0.7558 | 0.4201 | 0.9859 | 1.6064 | |
| 21MT-1 | HER2amp | - | Torkinib | 15382.211 | uM | 0.01093 | 0.03899 | -0.2640 | -0.3399 | 0.4078 | 0.7366 | 0.9935 | 1.1714 | |||
| 21MT-1 | HER2amp | - | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14607.189 | uM | 0.44295 | 0.66473 | -0.8717 | -0.8791 | 2.4993 | 0.7149 | 0.9937 | 1.3733 | |
| 21MT-1 | HER2amp | - | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14191.189 | uM | 0.40746 | 0.57483 | -0.6146 | -0.6271 | 2.3620 | 0.6103 | 0.9968 | 2.9704 | |
| 21NT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14783.203 | uM | 3.0610 | 4.70130 | -0.8093 | -0.8292 | 2.2786 | 0.4078 | 0.9883 | 1.8667 | |
| 21NT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14783.203 | uM | 3.0610 | 4.70130 | -0.8093 | -0.8292 | 2.2786 | 0.4078 | 0.9883 | 1.8667 | |
| 21NT | HER2amp | - | Dichloroacetate | PDK | PDK | 13575.176 | uM | 7.46330 | 16.77450 | 0.7977 | -0.9991 | 1.3558 | 0.0319 | 0.6506 | 1.4733 | |
| 21NT | HER2amp | - | Disulfiram | Proteasome | Proteasome | 13575.174 | uM | 25.85920 | 36.60680 | -0.6014 | -0.8791 | 2.9191 | 0.1524 | 0.9863 | 1.5845 | |
| 21NT | HER2amp | - | Mebendazole | 13575.174 | uM | 0.70544 | 0.60467 | 0.2760 | 0.2687 | 5.0000 | 0.2944 | 0.9408 | 1.5845 | |||
| 21NT | HER2amp | - | Methylglyoxal | 13653.184 | uM | 371.60 | 1000.00000 | -0.9322 | -0.8591 | 1.0101 | 0.5941 | 0.9376 | 1.5871 | |||
| 21NT | HER2amp | - | MG-132 | Proteasome | Proteasome | 14194.189 | uM | 0.10310 | 0.10891 | -0.3512 | -0.1578 | 5.0000 | 0.6651 | 0.5943 | 2.3616 | |
| 21NT | HER2amp | - | MG-132 | Proteasome | Proteasome | 14194.189 | uM | 0.10310 | 0.10891 | -0.3512 | -0.1578 | 5.0000 | 0.6651 | 0.5943 | 2.3616 | |
| 21NT | HER2amp | - | MG-132 | Proteasome | Proteasome | 14610.189 | uM | 0.09536 | 0.14625 | -0.9556 | -0.9536 | 2.4958 | 0.9558 | 0.9950 | 1.0787 | |
| 21NT | HER2amp | - | MG-132 | Proteasome | Proteasome | 14610.189 | uM | 0.09536 | 0.14625 | -0.9556 | -0.9536 | 2.4958 | 0.9558 | 0.9950 | 1.0787 | |
| 21NT | HER2amp | - | Nelfinavir | 13575.174 | uM | 19.74930 | 24.7910 | -0.2090 | -0.6289 | 3.5820 | 0.0991 | 0.9947 | 1.5845 | |||
| 21NT | HER2amp | - | Ribavirin | 15383.211 | uM | inf | inf | 1.0074 | 1.0074 | 0.0000 | 0.0469 | 0.0000 | 1.0341 | |||
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 5895.067 | uM | 2.25070 | 4.57410 | -0.9091 | -1.0000 | 1.5491 | 0.3497 | 0.9692 | 1.4053 | |
| 184A1 | NM | Basal | Doxorubicin | TOP2 | TOP | 9047.121 | uM | 0.13985 | 0.26689 | -0.9987 | -0.9310 | 1.6271 | 0.9214 | 0.9807 | 0.7949 |