Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9146.122 | uM | inf | inf | 0.9694 | 0.9694 | 0.0000 | -0.0404 | -1.9847 | 1.3408 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7794.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.6812 | |
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9035.018 | uM | 536.59930 | 1000.00000 | 0.1872 | -0.0935 | 0.2755 | 0.2729 | 0.8107 | 2.1555 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 7793.018 | uM | 245.40250 | 372.22010 | -0.9147 | -0.9315 | 2.5250 | 0.5517 | 0.9016 | 1.3186 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9146.122 | uM | inf | 0.50973 | 0.5528 | 0.5712 | 1.2270 | 0.1353 | 0.9205 | 1.3408 | ||
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9035.017 | uM | 2.2380 | 6.31910 | -0.9109 | -0.9976 | 1.0569 | 0.5825 | 0.9942 | 2.2905 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 7793.007 | uM | 0.97073 | 1.86150 | -0.6733 | -0.6755 | 1.3129 | 0.4892 | 0.9947 | 1.3832 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 9146.121 | uM | 1.40740 | 2.19440 | -0.6284 | -0.6026 | 1.7804 | 0.4336 | 0.9975 | 1.1366 | |
| AU565 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 10880.155 | uM | 0.27813 | 0.23011 | 0.5266 | 0.3062 | 5.0000 | 0.3052 | 0.6953 | 1.5205 | |
| AU565 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 13030.002 | uM | 0.00092 | 0.00128 | -0.9104 | -0.8772 | 3.0709 | 1.3116 | 0.9975 | 0.5732 | |
| AU565 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9146.002 | uM | 0.00498 | 0.00636 | -0.6733 | -0.6767 | 3.4844 | 0.9399 | 0.9984 | 1.2611 | |
| AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9146.121 | uM | 0.10032 | 0.22291 | -0.9894 | -0.9912 | 1.3687 | 0.9716 | 0.9813 | 1.1366 | |
| AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 7793.007 | uM | 0.09387 | 0.22089 | -0.9529 | -0.9559 | 1.2490 | 0.9331 | 0.9887 | 1.3832 | |
| AU565 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 5900.092 | uM | 22.11190 | 37.99340 | 0.1765 | -0.8772 | 1.8718 | 0.0574 | 0.9942 | 2.6334 | |
| AU565 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 5901.091 | uM | 8.69220 | 14.69410 | -0.3289 | -0.5059 | 1.3314 | 0.1854 | 0.9974 | 1.9229 | |
| AU565 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 5901.074 | uM | 0.51180 | 1.05610 | -0.7095 | -0.6601 | 1.1618 | 0.7400 | 0.9963 | 1.8718 | |
| AU565 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 10880.156 | uM | 0.57383 | 7.51240 | -0.8788 | -1.0000 | 0.4272 | 0.4508 | 0.8269 | 1.5288 | |
| AU565 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 10880.149 | uM | inf | inf | 0.8678 | 0.8678 | 0.0000 | 0.0766 | 0.1343 | 1.6289 | |
| AU565 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 10880.154 | uM | inf | inf | 0.9251 | 0.9251 | 0.0000 | 0.0449 | -0.1660 | 1.7853 | |
| AU565 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7793.016 | uM | 0.65307 | 1.61880 | -0.6853 | -0.7468 | 1.0066 | 0.4341 | 0.9920 | 1.1616 | |
| AU565 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7794.016 | uM | 2.89250 | 6.50790 | -0.1897 | -0.4920 | 0.8449 | 0.2166 | 0.9973 | 1.9541 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| BT-474 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 7798.077 | uM | inf | inf | 0.8883 | 0.8883 | 0.0000 | -0.0257 | 0.4190 | 1.4371 | |
| BT-474 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9163.03 | uM | 26.3970 | 32.88280 | -0.9993 | -0.9998 | 5.0000 | 0.3249 | 0.9959 | 0.3535 |