Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9035.017 | uM | 234.20810 | 255.89090 | 0.0352 | -0.0320 | 0.6997 | 0.3489 | 0.9930 | 2.2905 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7793.001 | uM | 0.02405 | 0.02845 | -0.7415 | -0.6582 | 5.0000 | 0.9064 | 0.9803 | 1.1508 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7793.035 | uM | 7.14650 | 49.68870 | -0.3950 | -0.5513 | 0.3832 | 0.7305 | 0.9781 | 1.2119 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7794.017 | uM | 3.63770 | 2.00040 | 0.0921 | 0.3519 | 2.0349 | 0.4369 | 0.8863 | 1.9851 | |
| AU565 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 10880.143 | uM | 16.77060 | 49.34150 | -0.1493 | -0.2316 | 0.3527 | 0.4585 | 0.8930 | 1.6077 | |
| AU565 | HER2amp | Luminal | IKK16 | IKK | NFKB | 5900.093 | uM | 3.11010 | 4.89820 | -0.7771 | -0.7902 | 2.0869 | 0.3658 | 0.9980 | 2.3084 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7793.037 | uM | 0.05319 | 0.09484 | -0.5860 | -0.4080 | 1.0317 | 0.7361 | 0.9655 | 1.0948 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9146.037 | uM | 0.15634 | 3.69020 | -0.9186 | -1.0000 | 0.3475 | 0.5819 | 0.8060 | 1.2617 | |
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7793.016 | uM | 42.57250 | 65.16510 | -0.8497 | -1.0000 | 2.5806 | 0.2359 | 0.9519 | 1.1616 | ||
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 5901.067 | uM | 0.01802 | 0.02217 | -0.9025 | -0.7242 | 4.3172 | 0.9599 | 0.9934 | 1.8762 | |
| AU565 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 14113.189 | uM | 0.18071 | 0.20019 | -0.8904 | -0.3341 | 4.9988 | 0.6752 | 0.6217 | 1.4645 | |
| AU565 | HER2amp | Luminal | Methylglyoxal | 13030.184 | uM | 50.30640 | 183.32630 | -1.0000 | -1.0000 | 0.8496 | 0.9024 | 0.9717 | 0.5725 | |||
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 5900.085 | uM | 0.06568 | 0.05161 | 0.1731 | 0.2181 | 2.3770 | 0.5321 | 0.9953 | 2.6391 | |
| AU565 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 5901.084 | uM | inf | 0.02070 | 0.5836 | 0.6280 | 2.2705 | 0.2695 | 0.9321 | 1.7402 | |
| AU565 | HER2amp | Luminal | Mebendazole | 13030.174 | uM | 0.18370 | 0.22252 | -0.6848 | -0.2875 | 2.3698 | 0.6128 | 0.8771 | 0.8615 | |||
| AU565 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10880.154 | uM | 1.08830 | 3.54840 | -0.8526 | -1.0000 | 0.9295 | 0.4164 | 0.9828 | 1.7853 | |
| AU565 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 10880.154 | uM | 0.09840 | 0.14717 | -0.8337 | -0.8418 | 2.4521 | 0.7896 | 0.9984 | 1.7853 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 5900.098 | uM | 0.43942 | 0.39077 | 0.0705 | 0.0722 | 1.3282 | 0.2539 | 0.9959 | 2.2937 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 5901.098 | uM | 0.56327 | 0.46224 | 0.0695 | 0.1160 | 1.3353 | 0.2461 | 0.9831 | 1.8013 | |
| AU565 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 10880.149 | uM | 41.97630 | 133.38290 | 0.5726 | -1.0000 | 0.9503 | 0.0531 | 0.9147 | 1.6289 | |
| AU565 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 10880.144 | uM | inf | inf | 0.6567 | 0.6567 | 0.0000 | 0.2741 | 0.4357 | 1.8532 | |
| AU565 | HER2amp | Luminal | Methylglyoxal | 13149.184 | uM | 130.14740 | 469.55390 | -0.9992 | -1.0000 | 0.8562 | 0.7768 | 0.9575 | 0.8650 | |||
| AU565 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 5900.095 | uM | 0.00691 | 0.00842 | -0.9388 | -0.6706 | 4.3242 | 1.0928 | 0.9719 | 2.1880 | |
| AU565 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 5901.095 | uM | 0.00255 | 0.00310 | -0.9409 | -0.6979 | 4.4494 | 1.2292 | 0.9662 | 1.9104 | |
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7794.016 | uM | 10.77660 | 7.89410 | 0.0679 | 0.3945 | 5.0000 | 0.1625 | 0.6985 | 1.9541 |