Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10473.142 | uM | inf | inf | 0.9428 | 0.9428 | 0.0000 | 0.0415 | -0.0641 | 1.0815 | |
| CAMA-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10473.142 | uM | 5.70560 | 9.9930 | -0.9793 | -0.9990 | 1.9591 | 0.3434 | 0.9972 | 1.0815 | |
| HCC1187 | TNBC | Basal A | Baicalein | Lipoxygenase | Metabolism | 10518.072 | uM | 8.05840 | 44.66590 | -0.4627 | -1.0000 | 0.6415 | 0.3266 | 0.9675 | 1.2152 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 10518.087 | uM | 0.00488 | 0.02658 | -0.7747 | -0.7029 | 0.5176 | 0.9208 | 0.9758 | 1.1688 | |
| HCC1187 | TNBC | Basal A | IKK16 | IKK | NFKB | 10518.1 | uM | 3.67090 | 4.54520 | -0.9524 | -0.9540 | 4.9962 | 0.4542 | 0.9876 | 1.4056 | |
| HCC1187 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 10518.1 | uM | 1.72660 | 4.80140 | -0.1947 | -0.4091 | 0.5845 | 0.4171 | 0.980 | 1.4056 | |
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 10518.1 | uM | 11.85830 | 18.21780 | -0.9484 | -1.0000 | 2.5586 | 0.2835 | 0.9690 | 1.4056 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 10518.135 | uM | 1.13960 | 1.24570 | -0.1218 | -0.0812 | 1.6904 | 0.3563 | 0.9831 | 1.1446 | |
| HCC1187 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 10518.135 | uM | inf | inf | 0.4907 | 0.4907 | 0.0000 | 0.1417 | 0.0602 | 1.1446 | |
| HCC1187 | TNBC | Basal A | PD 98059 | MEK | MAPK | 10518.136 | uM | 5.70580 | 6.65780 | -0.0226 | -0.0746 | 0.9009 | 0.2276 | 0.9698 | 1.2490 | |
| HCC1187 | TNBC | Basal A | Sulindac sulfide | COX1/2 | COX | 10518.136 | uM | 927.95440 | 1000.00000 | 0.7851 | -0.0259 | 0.6766 | 0.0394 | 0.6183 | 1.2490 | |
| HCC1187 | TNBC | Basal A | Celecoxib | COX2 | COX | 10518.136 | uM | inf | inf | 0.9091 | 0.9091 | 0.0000 | 0.0220 | 0.1805 | 1.2490 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 10518.137 | uM | 25.61280 | 147.06970 | 0.4349 | -1.0000 | 0.6286 | 0.1216 | 0.7415 | 1.2405 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 10518.137 | uM | 10.91310 | 8.45570 | 0.3599 | 0.3592 | 4.9678 | 0.0766 | 0.9090 | 1.2405 | |
| HCC1187 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 10518.138 | uM | 0.43471 | 0.58591 | -0.2990 | -0.2511 | 1.3632 | 0.3973 | 0.9939 | 1.3413 | ||
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10518.138 | uM | 0.23611 | 0.23002 | 0.0120 | 0.0612 | 5.0000 | 0.4780 | 0.9213 | 1.3413 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10518.138 | uM | 0.09728 | 0.11455 | -0.5380 | -0.2289 | 2.3063 | 0.6356 | 0.9308 | 1.3413 | |
| HCC1187 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 10518.139 | uM | 1.20340 | 1.41520 | -0.7378 | -0.6246 | 5.0000 | 0.5809 | 0.9830 | 1.2366 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 10518.139 | uM | 0.69804 | 0.96064 | -0.1654 | -0.1996 | 1.0518 | 0.3517 | 0.9913 | 1.2366 | |
| HCC1187 | TNBC | Basal A | GW843682X | PLK | PLK | 10518.139 | uM | 9.37850 | 81.90440 | 0.2153 | -1.0000 | 0.5069 | 0.1636 | 0.9748 | 1.2366 | |
| HCC1187 | TNBC | Basal A | Chk2 inhibitor II | CHK2 | CHK | 10518.14 | uM | inf | 9.15840 | 0.6700 | 0.6648 | 2.0740 | 0.0394 | 0.9522 | 1.2052 | |
| HCC1187 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 10518.14 | uM | 1.98340 | 2.49030 | -0.9784 | -0.9747 | 4.7532 | 0.6282 | 0.9973 | 1.2052 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 10518.14 | uM | 1.0160 | 1.24260 | -0.8690 | -0.8683 | 5.0000 | 0.4833 | 0.9979 | 1.2052 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 10518.141 | uM | 1.80660 | 1.25980 | 0.1622 | 0.1140 | 0.7180 | 0.2657 | 0.9263 | 1.3122 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10518.141 | uM | 4.60660 | 11.04240 | -0.9668 | -1.0000 | 1.2566 | 0.3372 | 0.9742 | 1.3122 |