Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Antibody	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
HCC1419	HER2amp	Luminal	Cetuximab	EGFR	ErbB	7820.042	uM	inf	inf	1.0221	1.0221	0.0000	-0.0483	-28.6122	0.5216
HCC1419	HER2amp	Luminal	Cetuximab	EGFR	ErbB	10019.124	uM	inf	inf	0.9810	0.9810	0.0000	-0.0457	-3.7312	0.5356
HCC1419	HER2amp	Luminal	Cetuximab	EGFR	ErbB	7821.042	uM	inf	inf	0.7843	0.7843	0.0000	0.1193	-0.0824	0.5522
HCC1419	HER2amp	Luminal	Cetuximab	EGFR	ErbB	9278.026	uM	inf	inf	0.8659	0.8659	0.0000	0.0594	-0.0671	0.3395
HCC1428	HR+	Luminal	Cetuximab	EGFR	ErbB	7441.102	uM	inf	inf	0.9761	0.9761	0.0000	0.0202	0.1949	0.9144
HCC1569	HER2amp	Basal A	Cetuximab	EGFR	ErbB	7824.018	uM	inf	inf	1.0500	1.0500	0.0000	-0.0500	-inf	1.3115
HCC1569	HER2amp	Basal A	Cetuximab	EGFR	ErbB	9347.026	uM	inf	inf	1.0500	1.0500	0.0000	-0.0441	-22.3629	1.2965
HCC1569	HER2amp	Basal A	Cetuximab	EGFR	ErbB	7447.102	uM	inf	inf	0.9613	0.9613	0.0000	0.0386	0.0310	1.6467
HCC70	TNBC	Basal A	Cetuximab	EGFR	ErbB	7857.042	uM	inf	0.00139	0.7456	0.7944	5.0000	0.1040	0.8457	1.1910
HCC70	TNBC	Basal A	Cetuximab	EGFR	ErbB	7856.018	uM	inf	inf	0.8811	0.8811	0.0000	0.0121	0.4683	0.9388
HCC1806	TNBC	Basal A	Cetuximab	EGFR	ErbB	7830.018	uM	inf	inf	0.8437	0.8437	0.0000	-0.0352	0.4991	1.5320
HCC1806	TNBC	Basal A	Cetuximab	EGFR	ErbB	9376.026	uM	inf	0.00355	0.6382	0.6973	1.1036	0.0999	0.9151	1.6827
AU565	HER2amp	Luminal	Cetuximab	EGFR	ErbB	7793.018	uM	inf	inf	0.9318	0.9318	0.0000	0.0067	0.3477	1.3186
184B5	NM	Basal	Cetuximab	EGFR	ErbB	9095.026	uM	0.04089	0.03186	0.1205	0.1008	0.9024	0.1873	0.9743	1.0168
600MPE	HR+	Luminal	Cetuximab	EGFR	ErbB	9118.006	uM	inf	inf	0.8545	0.8545	0.0000	0.0747	0.3005	1.1089
600MPE	HR+	Luminal	Cetuximab	EGFR	ErbB	7791.018	uM	inf	inf	0.8577	0.8577	0.0000	-0.0332	0.4860	0.8558
184A1	NM	Basal	Cetuximab	EGFR	ErbB	7787.018	uM	inf	inf	0.4652	0.4652	0.0000	0.3838	-0.0013	0.3791
AU565	HER2amp	Luminal	Cetuximab	EGFR	ErbB	9035.018	uM	inf	inf	0.9083	0.9083	0.0000	0.0297	0.4162	2.1555
HCC1187	TNBC	Basal A	Cetuximab	EGFR	ErbB	7812.042	uM	inf	inf	0.5614	0.5614	0.0000	0.0267	0.3674	0.9722
BT-20	TNBC	Basal A	Cetuximab	EGFR	ErbB	5903.102	uM	inf	0.01035	0.7898	0.7837	0.8245	0.0669	0.9137	1.2557
184A1	NM	Basal	Cetuximab	EGFR	ErbB	9047.026	uM	0.00360	0.01403	-0.2605	-0.4617	0.4805	0.4918	0.8777	0.5972
BT-474	HER2amp	Luminal	Cetuximab	EGFR	ErbB	9158.123	uM	inf	inf	0.7610	0.7610	0.0000	0.0813	0.5069	0.8769
BT-483	HR+	Luminal	Cetuximab	EGFR	ErbB	7801.018	uM	inf	inf	0.7533	0.7533	0.0000	0.1055	0.0672	0.5913
LY2	HR+	Luminal	Cetuximab	EGFR	ErbB	10264.026	uM	inf	inf	0.9706	0.9706	0.0000	-0.0006	0.1039	1.5047
LY2	HR+	Luminal	Cetuximab	EGFR	ErbB	7865.018	uM	inf	inf	-0.1870	-0.1870	0.0000	0.5240	-0.0010	1.1920

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)