Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 21MT-1 | HER2amp | - | Mebendazole | 13719.174 | uM | 31.97060 | 77.55140 | 0.0875 | -1.0000 | 1.2398 | 0.1610 | 0.8782 | 0.8124 | |||
| 21MT-1 | HER2amp | - | Methylglyoxal | 13719.184 | uM | 680.32080 | 999.99990 | -0.9954 | -0.9645 | 2.7899 | 0.6345 | 0.9961 | 0.7600 | |||
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| 184A1 | NM | Basal | Taxol | TUBB | TUBB | 9047.002 | uM | 0.05134 | 0.13706 | -0.1958 | -0.2758 | 0.4473 | 0.5388 | 0.9220 | 0.5243 | |
| 184A1 | NM | Basal | GSK461364 | PLK1 | PLK | 10002.001 | uM | 6.06620 | 9.11620 | -0.9717 | -1.0000 | 2.6972 | 0.2605 | 0.9735 | 0.5372 | |
| 184B5 | NM | Basal | QNZ | NFkB | NFKB | 5897.096 | uM | 0.03394 | 0.04191 | -0.9427 | -0.9339 | 4.9999 | 1.0267 | 0.9995 | 1.2810 | |
| 184B5 | NM | Basal | Purvalanol A | CDK1 | CDK | 5897.067 | uM | 12.87360 | 13.92180 | -0.3686 | -0.2376 | 4.9663 | 0.2133 | 0.9779 | 1.1908 | |
| 184A1 | NM | Basal | TAPI-0 | TACE/Collagenase | 5895.096 | uM | inf | 6.62580 | 0.8804 | 0.8803 | 5.0000 | -0.0065 | 0.5959 | 1.4232 | ||
| 184B5 | NM | Basal | Purvalanol A | CDK1 | CDK | 5896.067 | uM | 2.11650 | 1.66090 | 0.2353 | 0.3509 | 4.9920 | 0.2073 | 0.9594 | 1.4536 | |
| 184B5 | NM | Basal | PS-1145 | IKK | NFKB | 5897.065 | uM | inf | inf | 0.9561 | 0.9561 | 0.0000 | 0.0500 | 0.3340 | 1.2996 | |
| 184A1 | NM | Basal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5895.067 | uM | 5.42490 | 7.97390 | -0.9135 | -0.9079 | 2.6878 | 0.4188 | 0.9982 | 1.4053 | |
| 184A1 | NM | Basal | GSK461364 | PLK1 | PLK | 9047.001 | uM | 4.15810 | 52.44110 | -0.0073 | -1.0000 | 0.4334 | 0.2620 | 0.7464 | 0.7701 | |
| 184A1 | NM | Basal | Dichloroacetate | PDK | PDK | 12684.176 | uM | inf | inf | 0.9148 | 0.9148 | 0.0000 | 0.0449 | 0.1851 | 1.3650 | |
| 184B5 | NM | Basal | PS-1145 | IKK | NFKB | 5896.065 | uM | inf | inf | 0.9046 | 0.9046 | 0.0000 | 0.0309 | 0.3134 | 1.4978 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5897.095 | uM | 0.52125 | 0.66097 | -0.3237 | -0.3105 | 2.0341 | 0.8593 | 0.9969 | 1.2197 | |
| 184A1 | NM | Basal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5894.067 | uM | 4.440 | 8.19730 | -0.9413 | -0.9957 | 1.7870 | 0.4582 | 0.9949 | 1.5647 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5896.095 | uM | 0.24202 | 0.32119 | -0.2838 | -0.2743 | 1.5454 | 0.9106 | 0.9931 | 1.5532 | |
| 184B5 | NM | Basal | PD184352 | MEK | MAPK | 12566.155 | uM | 3.29320 | 33.01680 | -0.0750 | -1.0000 | 0.4766 | 0.2503 | 0.9170 | 1.5389 | |
| 184A1 | NM | Basal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5894.084 | uM | 3.93680 | 6.19440 | -0.5995 | -0.4573 | 1.4330 | 0.5586 | 0.9851 | 1.5903 | |
| 184A1 | NM | Basal | GSK1838705A | IGF1R | RTK | 5894.098 | uM | 0.36902 | 0.35227 | 0.0333 | 0.0487 | 2.2061 | 0.3782 | 0.9970 | 1.6523 | |
| 184B5 | NM | Basal | PD184352 | MEK | MAPK | 12566.155 | uM | 3.29320 | 33.01680 | -0.0750 | -1.0000 | 0.4766 | 0.2503 | 0.9170 | 1.5389 | |
| 184B5 | NM | Basal | PD173074 | FGFR1/3 | RTK | 5897.093 | uM | 28.42620 | 33.05570 | 0.2039 | -0.5632 | 4.9999 | 0.0088 | 0.9753 | 1.2047 | |
| 184A1 | NM | Basal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5895.085 | uM | 1.60350 | 2.04080 | -0.6352 | -0.4548 | 2.6820 | 0.5481 | 0.9684 | 1.4396 | |
| 184B5 | NM | Basal | PD 98059 | MEK | MAPK | 12566.152 | uM | inf | inf | 0.9069 | 0.9069 | 0.0000 | 0.0066 | 0.4227 | 1.4827 |