Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | AG1024 | IGF1R | RTK | 7516.066 | uM | inf | inf | 0.9266 | 0.9266 | 0.0000 | 0.0337 | 0.0627 | 1.1944 | |
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 7472.066 | uM | inf | inf | 0.9265 | 0.9265 | 0.0000 | -0.0306 | 0.0660 | 1.8363 | |
| MDA-MB-134-VI | HR+ | Luminal | Sulindac sulfide | COX1/2 | COX | 10519.136 | uM | inf | inf | 0.9265 | 0.9265 | 0.0000 | 0.0200 | 0.0000 | 1.1406 | |
| MDA-MB-361 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 7506.096 | uM | inf | inf | 0.9262 | 0.9262 | 0.0000 | 0.0039 | 0.4959 | 1.0303 | ||
| HCC70 | TNBC | Basal A | SB-3CT | MMP2/9 | MMP | 12400.168 | uM | inf | 8.51570 | 0.9069 | 0.9261 | 4.9761 | 0.0190 | 0.6824 | 1.3275 | |
| BT-483 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10696.154 | uM | inf | inf | 0.9257 | 0.9257 | 0.0000 | 0.0501 | 0.0000 | 0.6070 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 7874.05 | uM | inf | inf | 0.9256 | 0.9256 | 0.0000 | 0.0249 | 0.5118 | 1.5863 | |
| 184B5 | NM | Basal | Nilotinib | ABL | nRTK | 12566.17 | uM | inf | 0.08710 | 0.9223 | 0.9254 | 0.8046 | 0.0464 | 0.8541 | 1.4648 | |
| HCC1937 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7453.098 | uM | inf | inf | 0.9252 | 0.9252 | 0.0000 | 0.0007 | 0.1372 | 1.4660 | |
| AU565 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 10880.154 | uM | inf | inf | 0.9251 | 0.9251 | 0.0000 | 0.0449 | -0.1660 | 1.7853 | |
| MCF12A | NM | Basal B | Nilotinib | ABL | nRTK | 12365.17 | uM | inf | inf | 0.9251 | 0.9251 | 0.0000 | 0.0829 | 0.0001 | 2.2930 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 12319.155 | uM | inf | inf | 0.9243 | 0.9243 | 0.0000 | 0.2716 | 0.2645 | 0.9333 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7447.066 | uM | inf | inf | 0.9240 | 0.9240 | 0.0000 | -0.0284 | 0.0463 | 1.5813 | |
| 21MT-1 | HER2amp | - | Dichloroacetate | PDK | PDK | 13719.176 | uM | inf | inf | 0.9233 | 0.9233 | 0.0000 | 0.0596 | -0.2426 | 0.8672 | |
| HCC38 | TNBC | Basal B | AG1478 | EGFR | ErbB | 9453.019 | uM | inf | inf | 0.9233 | 0.9233 | 0.0000 | 0.0531 | 0.3590 | 1.1486 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10693.149 | uM | inf | inf | 0.9231 | 0.9231 | 0.0000 | -0.0023 | 0.5446 | 0.8714 | |
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 10579.138 | uM | inf | inf | 0.9224 | 0.9224 | 0.0000 | 0.0099 | 0.1840 | 0.9860 | ||
| SUM52PE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7541.084 | uM | inf | inf | 0.9224 | 0.9224 | 0.0000 | 0.0098 | 0.2324 | 1.2092 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7493.067 | uM | inf | inf | 0.9222 | 0.9222 | 0.0000 | 0.0803 | 0.0000 | 1.3684 | |
| BT-474 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12178.135 | uM | inf | inf | 0.9217 | 0.9217 | 0.0000 | -0.0119 | 0.2808 | 0.5524 | |
| UACC-812 | HER2amp | Luminal | Celecoxib | COX2 | COX | 10580.136 | uM | inf | inf | 0.9217 | 0.9217 | 0.0000 | 0.1643 | 0.0000 | 0.7205 | |
| AU565 | HER2amp | Luminal | GM6001 | MMP | MMP | 5900.096 | uM | inf | inf | 0.9215 | 0.9215 | 0.0000 | 0.0442 | 0.2561 | 2.7795 | |
| SK-BR-3 | HER2amp | Luminal | GM6001 | MMP | MMP | 7527.096 | uM | inf | inf | 0.9212 | 0.9212 | 0.0000 | 0.0674 | -0.2316 | 2.1119 | |
| T47DKBLUC | Unknown | Unknown | Erlotinib | EGFR | ErbB | 7545.092 | uM | inf | inf | 0.9211 | 0.9211 | 0.0000 | -0.0109 | 0.4842 | 0.9794 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7464.098 | uM | inf | inf | 0.9208 | 0.9208 | 0.0000 | 0.0740 | 0.2911 | 0.6305 |