Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
184A1 | NM | Basal | Dichloroacetate | PDK | PDK | 12684.176 | uM | inf | inf | 0.9148 | 0.9148 | 0.0000 | 0.0449 | 0.1851 | 1.3650 | |
184A1 | NM | Basal | PD 98059 | MEK | MAPK | 12509.152 | uM | inf | inf | 0.7622 | 0.7622 | 0.0000 | 0.0595 | 0.4482 | 1.3755 | |
184A1 | NM | Basal | PS-1145 | IKK | NFKB | 5894.065 | uM | inf | 416.61250 | 0.8384 | 0.8383 | 4.9997 | -0.0087 | 0.7490 | 1.6064 | |
184A1 | NM | Basal | Docetaxel | TUBB | TUBB | 10002.002 | uM | inf | 0.00813 | 0.5141 | 0.5151 | 1.4431 | 0.2780 | 0.7979 | 0.9502 | |
184A1 | NM | Basal | Docetaxel | TUBB | TUBB | 12684.002 | uM | inf | 0.00450 | 0.5376 | 0.5289 | 1.1663 | 0.2796 | 0.9570 | 1.5245 | |
184B5 | NM | Basal | ZM-447439 | AURK | AURK | 12566.169 | uM | inf | 0.69572 | 0.6262 | 0.6434 | 1.3748 | 0.1369 | 0.9197 | 1.6359 | |
184A1 | NM | Basal | PS-1145 | IKK | NFKB | 5895.065 | uM | inf | inf | 1.0031 | 1.0031 | 0.0000 | -0.0389 | -4.6402 | 1.3748 | |
184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 7787.018 | uM | inf | inf | 0.4652 | 0.4652 | 0.0000 | 0.3838 | -0.0013 | 0.3791 | |
184B5 | NM | Basal | Sirolimus | MTOR | MTOR | 7789.068 | uM | inf | inf | -0.9304 | -0.9304 | 0.0000 | 1.0723 | 0.4470 | 0.3219 | |
184A1 | NM | Basal | Baicalein | Lipoxygenase | Metabolism | 5895.073 | uM | inf | 35.38250 | 0.5990 | 0.5817 | 2.0246 | 0.0235 | 0.9408 | 1.4431 | |
184A1 | NM | Basal | Taxol | TUBB | TUBB | 12684.002 | uM | inf | 0.01616 | 0.4397 | 0.5237 | 1.5161 | 0.2820 | 0.9561 | 1.5245 | |
184A1 | NM | Basal | JNK-IN-5A | JNK | JNK | 12509.168 | uM | inf | 0.95387 | 0.3859 | 0.6171 | 4.9990 | 0.1487 | 0.7274 | 1.3516 | |
184A1 | NM | Basal | TAPI-0 | TACE/Collagenase | 5895.096 | uM | inf | 6.62580 | 0.8804 | 0.8803 | 5.0000 | -0.0065 | 0.5959 | 1.4232 | ||
184B5 | NM | Basal | Cisplatin | DNA cross-linker | DNA cross-linker | 9095.049 | uM | inf | 193.58440 | 0.7160 | 0.7080 | 3.7384 | 0.0137 | 0.8937 | 1.1202 | |
184A1 | NM | Basal | Trastuzumab | HER2 | ErbB | 9047.026 | uM | inf | inf | 0.2837 | 0.2837 | 0.0000 | 0.2170 | 0.0804 | 0.5972 | |
184A1 | NM | Basal | FTase Inhibitor I | Ftase | MAPK | 12509.167 | uM | inf | inf | 0.9988 | 0.9988 | 0.0000 | -0.0033 | -0.0009 | 1.4256 | |
184A1 | NM | Basal | Gefitinib | EGFR | ErbB | 9047.132 | uM | inf | inf | 0.4414 | 0.4414 | 0.0000 | 0.4398 | 0.3588 | 0.6985 | |
184A1 | NM | Basal | Mebendazole | 12684.174 | uM | inf | 0.36667 | 0.5334 | 0.5745 | 5.0000 | 0.1723 | 0.9699 | 1.4645 | |||
184A1 | NM | Basal | GSK923295 | CENPE | Kinesin | 9047.001 | uM | inf | inf | 0.0385 | 0.0385 | 0.0000 | 0.2510 | 0.5226 | 0.7701 | |
184A1 | NM | Basal | Sirolimus | MTOR | MTOR | 7787.068 | uM | inf | inf | -0.2794 | -0.2794 | 0.0000 | 0.5821 | 0.4995 | 0.9562 | |
184A1 | NM | Basal | Glycyl-H-1152 | ROCK2 | 12509.169 | uM | inf | inf | 0.8820 | 0.8820 | 0.0000 | 0.0673 | 0.0092 | 1.5064 | ||
184A1 | NM | Basal | GM6001 | MMP | MMP | 5895.096 | uM | inf | inf | 0.9763 | 0.9763 | 0.0000 | -0.0141 | -0.1057 | 1.4232 | |
184A1 | NM | Basal | ZM-447439 | AURK | AURK | 12509.169 | uM | inf | 1.20210 | 0.5422 | 0.5277 | 0.9240 | 0.1592 | 0.9369 | 1.5064 | |
184A1 | NM | Basal | Vinorelbine | TUBB | TUBB | 7787.018 | uM | inf | inf | -0.9963 | -0.9963 | 0.0000 | 0.4831 | 0.4499 | 0.3791 | |
184A1 | NM | Basal | (Z)-4-Hydroxytamoxifen | ESR1 | 9047.132 | uM | inf | inf | 0.4055 | 0.4055 | 0.0000 | 0.2074 | 0.3073 | 0.6985 |