Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Ribavirin | 15385.211 | uM | inf | inf | 0.4315 | 0.4315 | 0.0000 | 0.1628 | 0.4682 | 0.7321 | |||
| BT-474 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 12291.167 | uM | inf | inf | 0.6966 | 0.6966 | 0.0000 | 0.2525 | 0.0928 | 0.6147 | |
| BT-549 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 12305.155 | uM | inf | inf | 0.8866 | 0.8866 | 0.0000 | 0.1682 | 0.3058 | 2.8841 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7793.012 | uM | inf | inf | 1.0078 | 1.0078 | 0.0000 | -0.0215 | -0.0764 | 1.1030 | |
| BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9158.123 | uM | inf | inf | 0.7610 | 0.7610 | 0.0000 | 0.0813 | 0.5069 | 0.8769 | |
| BT-20 | TNBC | Basal A | PS-1145 | IKK | NFKB | 10385.065 | uM | inf | inf | 0.4664 | 0.4664 | 0.0000 | 0.3016 | 0.3040 | 0.6599 | |
| AU565 | HER2amp | Luminal | GM6001 | MMP | MMP | 5900.096 | uM | inf | inf | 0.9215 | 0.9215 | 0.0000 | 0.0442 | 0.2561 | 2.7795 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7793.018 | uM | inf | inf | 0.9318 | 0.9318 | 0.0000 | 0.0067 | 0.3477 | 1.3186 | |
| 600MPE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9118.001 | uM | inf | inf | 0.5960 | 0.5960 | 0.0000 | 0.1146 | 0.4985 | 1.0946 | |
| 21MT-1 | HER2amp | - | Ribavirin | 15382.211 | uM | inf | inf | 0.9683 | 0.9683 | 0.0000 | 0.0416 | 0.0000 | 1.1714 | |||
| AU565 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5900.085 | uM | inf | inf | 0.5199 | 0.5199 | 0.0000 | 0.0667 | 0.2964 | 2.6391 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9163.03 | uM | inf | inf | -0.5674 | -0.5674 | 0.0000 | 0.6950 | 0.4965 | 0.3535 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 5902.066 | uM | inf | inf | 0.9990 | 0.9990 | 0.0000 | -0.0235 | -0.9254 | 1.1775 | |
| 600MPE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9120.001 | uM | inf | inf | 0.4795 | 0.4795 | 0.0000 | 0.1244 | 0.2915 | 0.6180 | |
| BT-474 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 5906.067 | uM | inf | inf | 0.9890 | 0.9890 | 0.0000 | -0.0331 | -0.7588 | 0.6838 | |
| 184A1 | NM | Basal | Trastuzumab | HER2 | ErbB | 9047.026 | uM | inf | inf | 0.2837 | 0.2837 | 0.0000 | 0.2170 | 0.0804 | 0.5972 | |
| 600MPE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 12224.155 | uM | inf | inf | 0.7744 | 0.7744 | 0.0000 | 0.1982 | 0.2284 | 1.0378 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9158.001 | uM | inf | inf | -0.9965 | -0.9965 | 0.0000 | 0.3194 | 0.2618 | 0.6988 | |
| AU565 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10880.155 | uM | inf | inf | 0.9535 | 0.9535 | 0.0000 | 0.0209 | -0.0479 | 1.5205 | |
| 600MPE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 12224.16 | uM | inf | inf | 0.9729 | 0.9729 | 0.0000 | 0.0688 | 0.1842 | 0.7734 | ||
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 12224.072 | uM | inf | inf | 0.8349 | 0.8349 | 0.0000 | 0.1299 | -0.0188 | 1.0105 | |
| 600MPE | HR+ | Luminal | AG1024 | IGF1R | RTK | 5899.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0165 | 0.0780 | 0.7056 | |
| 600MPE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12224.135 | uM | inf | inf | 0.7869 | 0.7869 | 0.0000 | 0.0993 | 0.1270 | 1.0314 | |
| CAMA-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 12070.155 | uM | inf | inf | 0.8551 | 0.8551 | 0.0000 | 0.0592 | -0.0020 | 1.1729 | |
| CAMA-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 12070.155 | uM | inf | inf | 0.8551 | 0.8551 | 0.0000 | 0.0592 | -0.0020 | 1.1729 |