Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7436.074 | uM | 0.04608 | 0.07970 | -0.8305 | -0.8281 | 1.7831 | 1.1039 | 0.9977 | 1.2173 | |
| HCC1395 | TNBC | Basal B | Bosutinib | Src | nRTK | 12000.145 | uM | 0.99402 | 1.66680 | -0.9978 | -0.9879 | 2.1096 | 0.6757 | 0.9883 | 0.6084 | |
| HCC1395 | TNBC | Basal B | Bosutinib | Src | nRTK | 12084.145 | uM | 1.06290 | 2.1380 | -0.9906 | -1.0000 | 1.5719 | 0.6041 | 0.9896 | 1.1692 | |
| HCC1395 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7814.011 | uM | 10.88860 | 30.9870 | -0.9745 | -1.0000 | 1.0504 | 0.6110 | 0.9920 | 0.9472 | |
| HCC1395 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7813.011 | uM | 12.70740 | 28.0090 | -0.9984 | -0.9925 | 1.3837 | 0.5964 | 0.9925 | 0.8718 | |
| HCC1395 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 9258.011 | uM | 8.63850 | 22.84430 | -0.9974 | -1.0000 | 1.1297 | 0.6494 | 0.9947 | 0.6984 | |
| HCC1395 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 9254.12 | uM | 10.65980 | 25.03080 | -0.9670 | -0.9893 | 1.2786 | 0.6184 | 0.9964 | 1.1139 | |
| HCC1395 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7816.042 | uM | inf | inf | 1.0005 | 1.0005 | 0.0000 | -0.0101 | -0.0006 | 0.9332 | |
| HCC1395 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 9258.026 | uM | inf | inf | 0.7953 | 0.7953 | 0.0000 | 0.0354 | 0.3593 | 0.5632 | |
| HCC1395 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7813.018 | uM | 0.82620 | 0.82952 | 0.7195 | -0.0101 | 4.9982 | 0.0073 | 0.6447 | 0.8420 | |
| HCC1395 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 9254.124 | uM | 1.07170 | 0.71327 | 0.7439 | 0.4322 | 4.9081 | -0.0186 | 0.7673 | 0.8067 | |
| HCC1395 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7814.042 | uM | 1.1580 | 1.97410 | 0.7528 | -0.7381 | 1.6997 | 0.0120 | 0.7787 | 0.8414 | |
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9254.124 | uM | 26.98710 | 1000.00000 | 0.1010 | -0.7823 | 0.2607 | 0.2991 | 0.7092 | 0.8067 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9258.026 | uM | 0.44087 | 35.50130 | -1.0000 | -1.0000 | 0.2503 | 0.8247 | 0.7494 | 0.5632 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7813.018 | uM | 67.35460 | 248.74160 | -0.9987 | -1.0000 | 0.8409 | 0.6221 | 0.8654 | 0.8420 | ||
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7816.017 | uM | inf | inf | 0.9626 | 0.9626 | 0.0000 | 0.1531 | 0.2853 | 1.2318 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7814.017 | uM | 0.85473 | 2.24240 | -0.9949 | -1.0000 | 1.1390 | 0.7631 | 0.9837 | 0.8254 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9258.03 | uM | 1.05110 | 2.06760 | -1.0000 | -1.0000 | 1.6238 | 0.7227 | 0.9985 | 0.4015 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7813.017 | uM | 1.51090 | 3.07860 | -0.9985 | -0.9967 | 1.5404 | 0.6591 | 0.9985 | 0.8685 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9254.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.8730 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 7816.007 | uM | inf | 0.29274 | 0.6524 | 0.6771 | 0.9101 | 0.1492 | 0.8626 | 1.1536 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 7813.007 | uM | 0.40394 | 0.43618 | -0.7377 | -0.2341 | 5.0000 | 0.4623 | 0.8679 | 0.8361 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 9254.121 | uM | 1.88410 | 7.72860 | -0.6959 | -0.9260 | 0.7425 | 0.3745 | 0.9815 | 1.2352 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 9258.121 | uM | 0.8180 | 1.81820 | -0.9944 | -0.9150 | 1.3024 | 0.6132 | 0.9822 | 0.4800 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 12000.155 | uM | inf | inf | 0.6675 | 0.6675 | 0.0000 | 0.2919 | 0.2735 | 0.8592 |