Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
BT-20
TNBC
Basal A
 MG-132
Proteasome
Proteasome
14230.189
uM
0.13122
0.14986
 -1.0000 -0.4715 5.0000 0.7755
0.5873
 0.4635
BT-20
TNBC
Basal A
 MG-132
Proteasome
Proteasome
14230.189
uM
0.13122
0.14986
 -1.0000 -0.4715 5.0000 0.7755
0.5873
 0.4635
BT-20
TNBC
Basal A
 MG-132
Proteasome
Proteasome
14116.189
uM
0.01949
0.02399
 -0.9999 -0.9133 4.9999 1.3281
0.7354
 0.5416
BT-20
TNBC
Basal A
 MG-132
Proteasome
Proteasome
14116.189
uM
0.01949
0.02399
 -0.9999 -0.9133 4.9999 1.3281
0.7354
 0.5416
BT-20
TNBC
Basal A
 MG-132
Proteasome
Proteasome
11854.145
uM
0.42398
0.66186
 -0.8339 -0.8480 2.2268 0.7053
0.9937
 1.1581
BT-20
TNBC
Basal A
 MG-132
Proteasome
Proteasome
11854.145
uM
0.42398
0.66186
 -0.8339 -0.8480 2.2268 0.7053
0.9937
 1.1581
BT-20
TNBC
Basal A
 MG-132
Proteasome
Proteasome
10581.145
uM
0.40995
0.51530
 -0.9238 -0.9118 4.5382 0.7453
0.9977
 0.9044
BT-20
TNBC
Basal A
 MG-132
Proteasome
Proteasome
10581.145
uM
0.40995
0.51530
 -0.9238 -0.9118 4.5382 0.7453
0.9977
 0.9044
BT-20
TNBC
Basal A
 Pevonedistat
NAE1
NAE1
10581.135
uM
1.47980
2.69010
 -0.9658 -0.9808 1.8166 0.5466
0.9693
 0.4426
BT-20
TNBC
Basal A
 Pevonedistat
NAE1
NAE1
11854.135
uM
2.68930
4.38360
 -0.6161 -0.6439 1.6939 0.4143
0.9783
 1.3170
BT-20
TNBC
Basal A
 Nelfinavir
13579.174
uM
6.73570
8.99950
 -0.9951 -1.0000 3.7916 0.2274
0.9935
 0.8018
BT-20
TNBC
Basal A
 Nilotinib
ABL
nRTK
11854.145
uM
inf
7.90530
 0.4616 0.5489 5.0000 0.1255
0.8664
 1.1581
BT-20
TNBC
Basal A
 Nilotinib
ABL
nRTK
10581.145
uM
16.74520
10.16160
 0.3643 0.3665 2.6440 0.1747
0.9485
 0.9044
BT-20
TNBC
Basal A
 NSC 663284
CDC25
CDC
10581.14
uM
2.50810
5.45180
 -0.9836 -1.0000 1.4150 0.6051
0.9839
 0.9569
BT-20
TNBC
Basal A
 NSC 663284
CDC25
CDC
11854.159
uM
4.23620
7.20050
 -0.9579 -0.9926 2.0617 0.5088
0.9963
 1.2639
BT-20
TNBC
Basal A
 NU6102
CDK1/2
CDK
11854.147
uM
47.26360
55.11040
 0.1866 -0.2809 2.9022 0.1030
0.9218
 1.2634
BT-20
TNBC
Basal A
 NU6102
CDK1/2
CDK
10581.147
uM
50.76880
59.00120
 0.0007 -0.5462 4.9127 0.0809
0.9756
 1.0319
BT-20
TNBC
Basal A
 Nutlin 3a
MDM2
MDM2
5904.066
uM
59.03660
67.82830
 0.3983 -0.2313 2.7389 0.0677
0.8527
 1.0078
BT-20
TNBC
Basal A
 Nutlin 3a
MDM2
MDM2
10385.066
uM
37.58360
57.99190
 -0.1627 -0.9815 2.5044 0.0990
0.9843
 0.7592
BT-20
TNBC
Basal A
 Nutlin 3a
MDM2
MDM2
5902.066
uM
34.66160
41.18670
 -0.1012 -0.3506 3.0803 0.0708
0.9881
 1.1775
BT-20
TNBC
Basal A
 Nutlin 3a
MDM2
MDM2
5903.066
uM
31.02030
46.85820
 -0.4317 -0.9929 2.6519 0.1035
0.9927
 1.1945
BT-20
TNBC
Basal A
 Olomoucine II
CDK1
CDK
11854.147
uM
4.19310
7.64250
 -0.5939 -0.6180 1.3405 0.3584
0.9938
 1.2634
BT-20
TNBC
Basal A
 Olomoucine II
CDK1
CDK
10581.147
uM
3.4120
7.31810
 -0.7048 -0.7814 1.2333 0.4250
0.9945
 1.0319
BT-20
TNBC
Basal A
 Omipalisib
PI3K
PI3K
10581.087
uM
0.01482
0.08871
 -0.9436 -0.9379 0.5904 0.9032
0.9863
 1.0948
BT-20
TNBC
Basal A
 Omipalisib
PI3K
PI3K
10385.087
uM
0.03901
0.10053
 -0.8607 -0.7565 0.9735 0.7953
0.9895
 0.9074