Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.138 | uM | 9958.034 | 0.7244 | 0.0781 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.69 | uM | 9958.034 | 0.4767 | -0.5166 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 3.45 | uM | 9958.034 | 0.5677 | -0.3244 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 17.2 | uM | 9958.034 | 0.6040 | -0.2391 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 9958.034 | 0.0102 | -0.9997 | 0.5217 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9972.121 | 1.0137 | 1.0247 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 9972.121 | 0.9622 | 0.9314 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9972.121 | 1.0160 | 1.0291 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9972.121 | 0.8315 | 0.6920 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 9972.121 | 0.7198 | 0.4847 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 9972.121 | 0.3745 | -0.1788 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9972.121 | 0.1337 | -0.6771 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9972.121 | 0.2059 | -0.5224 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 9972.121 | 0.0849 | -0.7860 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9997.121 | 1.1243 | 1.2222 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 9997.121 | 1.0273 | 1.0491 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9997.121 | 1.0363 | 1.0651 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9997.121 | 0.9840 | 0.9712 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 9997.121 | 0.8778 | 0.7788 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 9997.121 | 0.5905 | 0.2453 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9997.121 | 0.1652 | -0.6039 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9997.121 | 0.2081 | -0.5124 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 9997.121 | 0.0272 | -0.9219 | 1.1121 | |
| 184A1 | NM | Basal | Epirubicin | TOP2 | TOP | 0.000441 | uM | 9047.017 | 1.1378 | 1.3304 | 0.8440 | |
| 184A1 | NM | Basal | Epirubicin | TOP2 | TOP | 0.00221 | uM | 9047.017 | 0.9368 | 0.8510 | 0.8440 |