Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10880.15 | 0.9976 | 0.9970 | 1.5829 | |
| AU565 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10880.15 | 0.9344 | 0.9161 | 1.5829 | |
| AU565 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10880.15 | 0.6977 | 0.5932 | 1.5829 | |
| AU565 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10880.15 | 0.5822 | 0.4211 | 1.5829 | |
| AU565 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10880.15 | 0.7559 | 0.6759 | 1.5829 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.000256 | uM | 10581.138 | 0.9161 | 0.8230 | 0.9462 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.00128 | uM | 10581.138 | 0.9141 | 0.8189 | 0.9462 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0064 | uM | 10581.138 | 0.9371 | 0.8673 | 0.9462 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.032 | uM | 10581.138 | 0.9729 | 0.9428 | 0.9462 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.16 | uM | 10581.138 | 0.9409 | 0.8752 | 0.9462 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.8 | uM | 10581.138 | 0.8938 | 0.7761 | 0.9462 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 4 | uM | 10581.138 | 0.7630 | 0.5027 | 0.9462 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 20 | uM | 10581.138 | 0.6699 | 0.3096 | 0.9462 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 100 | uM | 10581.138 | 0.2813 | -0.4765 | 0.9462 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.000256 | uM | 11854.16 | 0.9198 | 0.8764 | 1.3102 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.00128 | uM | 11854.16 | 0.9270 | 0.8876 | 1.3102 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0064 | uM | 11854.16 | 0.9077 | 0.8575 | 1.3102 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.032 | uM | 11854.16 | 0.9304 | 0.8929 | 1.3102 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.16 | uM | 11854.16 | 0.9380 | 0.9046 | 1.3102 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.8 | uM | 11854.16 | 0.8471 | 0.7621 | 1.3102 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 4 | uM | 11854.16 | 0.6670 | 0.4682 | 1.3102 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 20 | uM | 11854.16 | 0.6136 | 0.3777 | 1.3102 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 100 | uM | 11854.16 | 0.5896 | 0.3364 | 1.3102 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 12056.16 | 0.9222 | 0.8301 | 0.9124 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 12056.16 | 0.9305 | 0.8482 | 0.9124 |