Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 12056.16 | 0.8978 | 0.7771 | 0.9124 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 12056.16 | 0.8872 | 0.7541 | 0.9124 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 12056.16 | 0.9252 | 0.8367 | 0.9124 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 12056.16 | 0.9091 | 0.8016 | 0.9124 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 12056.16 | 0.8495 | 0.6726 | 0.9124 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 12056.16 | 0.8232 | 0.6160 | 0.9124 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 12056.16 | 0.3107 | -0.4446 | 0.9124 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 12178.16 | 0.9495 | 0.8646 | 0.7392 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 12178.16 | 0.8816 | 0.6866 | 0.7392 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 12178.16 | 0.8844 | 0.6938 | 0.7392 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 12178.16 | 0.8809 | 0.6846 | 0.7392 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 12178.16 | 0.9310 | 0.8155 | 0.7392 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 12178.16 | 0.8454 | 0.5936 | 0.7392 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 12178.16 | 0.8862 | 0.6985 | 0.7392 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 12178.16 | 0.8313 | 0.5577 | 0.7392 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 12178.16 | 0.8669 | 0.6485 | 0.7392 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.000128 | uM | 12291.169 | 1.0061 | 1.0346 | 0.3548 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.00064 | uM | 12291.169 | 1.0824 | 1.5001 | 0.3548 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0032 | uM | 12291.169 | 1.0993 | 1.6120 | 0.3548 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.016 | uM | 12291.169 | 0.9377 | 0.6682 | 0.3548 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.08 | uM | 12291.169 | 1.0675 | 1.4045 | 0.3548 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.4 | uM | 12291.169 | 0.9522 | 0.7421 | 0.3548 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 2 | uM | 12291.169 | 0.9632 | 0.7996 | 0.3548 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 10 | uM | 12291.169 | 0.7679 | -0.0499 | 0.3548 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 50 | uM | 12291.169 | 0.8879 | 0.4305 | 0.3548 |