Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7517.065 | 0.9523 | 0.9360 | 1.5040 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7517.065 | 0.9386 | 0.9174 | 1.5040 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7517.065 | 0.7283 | 0.6199 | 1.5040 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7517.065 | 0.0410 | -0.7609 | 1.5040 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7517.065 | 0.0157 | -0.8739 | 1.5040 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7517.065 | 0.0150 | -0.8776 | 1.5040 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7517.065 | 0.0161 | -0.8717 | 1.5040 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7518.065 | 1.0527 | 1.0766 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7518.065 | 1.0879 | 1.1270 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7518.065 | 0.9986 | 0.9979 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7518.065 | 1.0577 | 1.0837 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7518.065 | 0.8048 | 0.7064 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7518.065 | 0.0847 | -0.6711 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7518.065 | 0.0408 | -0.8070 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7518.065 | 0.0308 | -0.8431 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7518.065 | 0.0237 | -0.8703 | 1.3677 | |
| MX1 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 0.048 | uM | 7523.065 | 1.0120 | 1.0314 | 0.7668 | |
| MX1 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 0.24 | uM | 7523.065 | 1.0836 | 1.2207 | 0.7668 | |
| MX1 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 1.2 | uM | 7523.065 | 1.0447 | 1.1174 | 0.7668 | |
| MX1 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 6 | uM | 7523.065 | 1.0305 | 1.0798 | 0.7668 | |
| MX1 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 30 | uM | 7523.065 | 0.9528 | 0.8778 | 0.7668 | |
| MX1 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 150 | uM | 7523.065 | 0.6587 | 0.1604 | 0.7668 | |
| MX1 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 750 | uM | 7523.065 | 0.3332 | -0.5229 | 0.7668 | |
| MX1 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 3750 | uM | 7523.065 | 0.0893 | -0.9143 | 0.7668 | |
| MX1 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 18700 | uM | 7523.065 | 0.0436 | -0.9664 | 0.7668 |