Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7440.065 | 0.3830 | -0.6158 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7440.065 | 0.0340 | -0.9940 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7440.065 | 0.0318 | -0.9947 | 0.5818 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7442.065 | 0.9778 | 0.9434 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7442.065 | 1.0243 | 1.0624 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7442.065 | 1.0079 | 1.0202 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7442.065 | 1.0029 | 1.0075 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7442.065 | 0.8724 | 0.6791 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7442.065 | 0.1417 | -0.8364 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7442.065 | 0.0144 | -0.9913 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7442.065 | 0.0135 | -0.9920 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7442.065 | 0.0112 | -0.9937 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7443.065 | 1.0070 | 1.0160 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7443.065 | 1.0379 | 1.0862 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7443.065 | 1.0250 | 1.0568 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7443.065 | 0.9827 | 0.9607 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7443.065 | 0.8382 | 0.6372 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7443.065 | 0.1301 | -0.8020 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7443.065 | 0.0176 | -0.9795 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7443.065 | 0.0159 | -0.9817 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7443.065 | 0.0125 | -0.9861 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7444.065 | 1.0134 | 1.0363 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7444.065 | 1.0355 | 1.0962 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7444.065 | 1.0036 | 1.0096 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7444.065 | 0.9897 | 0.9723 | 0.7419 |