Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 46.4 | uM | 7931.042 | 0.2808 | -0.1991 | 1.3878 | |
| ZR-75-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 0.000119 | uM | 7932.052 | 1.1094 | 1.2481 | 0.8877 | |
| ZR-75-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 0.000593 | uM | 7932.052 | 0.9773 | 0.9490 | 0.8877 | |
| ZR-75-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 0.00297 | uM | 7932.052 | 1.0697 | 1.1577 | 0.8877 | |
| ZR-75-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 0.0148 | uM | 7932.052 | 0.7264 | 0.3951 | 0.8877 | |
| ZR-75-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 0.0742 | uM | 7932.052 | 0.5668 | 0.0550 | 0.8877 | |
| ZR-75-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 0.371 | uM | 7932.052 | 0.5050 | -0.0736 | 0.8877 | |
| ZR-75-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 1.85 | uM | 7932.052 | 0.4985 | -0.0871 | 0.8877 | |
| ZR-75-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7932.052 | 0.4417 | -0.2033 | 0.8877 | |
| ZR-75-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 46.4 | uM | 7932.052 | 0.0726 | -0.8958 | 0.8877 | |
| ZR75B | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 0.000822 | uM | 9972.125 | 1.0165 | 1.0278 | 1.1854 | |
| ZR75B | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 0.00411 | uM | 9972.125 | 0.7039 | 0.4873 | 1.1854 | |
| ZR75B | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 0.0205 | uM | 9972.125 | 0.4923 | 0.0999 | 1.1854 | |
| ZR75B | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 0.103 | uM | 9972.125 | 0.4405 | 0.0016 | 1.1854 | |
| ZR75B | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 0.514 | uM | 9972.125 | 0.4431 | 0.0065 | 1.1854 | |
| ZR75B | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 2.57 | uM | 9972.125 | 0.4465 | 0.0130 | 1.1854 | |
| ZR75B | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 12.8 | uM | 9972.125 | 0.3319 | -0.2112 | 1.1854 | |
| ZR75B | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 64.2 | uM | 9972.125 | 0.0154 | -0.9408 | 1.1854 | |
| ZR75B | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 321 | uM | 9972.125 | 0.0111 | -0.9550 | 1.1854 | |
| 184A1 | NM | Basal | Vorinostat | HDAC | HDAC | 0.048 | uM | 5894.065 | 1.0014 | 1.0018 | 1.6064 | |
| 184A1 | NM | Basal | Vorinostat | HDAC | HDAC | 0.24 | uM | 5894.065 | 1.0457 | 1.0564 | 1.6064 | |
| 184A1 | NM | Basal | Vorinostat | HDAC | HDAC | 1.2 | uM | 5894.065 | 1.0177 | 1.0219 | 1.6064 | |
| 184A1 | NM | Basal | Vorinostat | HDAC | HDAC | 6 | uM | 5894.065 | 1.0427 | 1.0528 | 1.6064 | |
| 184A1 | NM | Basal | Vorinostat | HDAC | HDAC | 30 | uM | 5894.065 | 0.8858 | 0.8546 | 1.6064 | |
| 184A1 | NM | Basal | Vorinostat | HDAC | HDAC | 150 | uM | 5894.065 | 0.5783 | 0.4222 | 1.6064 |