Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 11660.143 | 0.1378 | -0.7032 | 1.0389 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12003.143 | 0.8350 | 0.7314 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 12003.143 | 0.8392 | 0.7382 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 12003.143 | 0.9313 | 0.8892 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 12003.143 | 0.9129 | 0.8594 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 12003.143 | 0.8377 | 0.7358 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 12003.143 | 0.8938 | 0.8282 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 12003.143 | 0.7420 | 0.5752 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 12003.143 | 0.5434 | 0.2278 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 12003.143 | 0.1454 | -0.5724 | 1.2499 | |
| ZR75B | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 11939.143 | 0.9544 | 0.9471 | 1.7414 | |
| ZR75B | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 11939.143 | 0.9774 | 0.9739 | 1.7414 | |
| ZR75B | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 11939.143 | 0.9805 | 0.9775 | 1.7414 | |
| ZR75B | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 11939.143 | 0.9757 | 0.9720 | 1.7414 | |
| ZR75B | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 11939.143 | 0.9273 | 0.9152 | 1.7414 | |
| ZR75B | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 11939.143 | 0.9364 | 0.9260 | 1.7414 | |
| ZR75B | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 11939.143 | 0.8678 | 0.8436 | 1.7414 | |
| ZR75B | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 11939.143 | 0.5194 | 0.3729 | 1.7414 | |
| ZR75B | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 11939.143 | 0.0199 | -0.7891 | 1.7414 | |
| 184A1 | NM | Basal | Vinorelbine | TUBB | TUBB | 0.000119 | uM | 7787.018 | 0.8243 | 0.2015 | 0.3791 | |
| 184A1 | NM | Basal | Vinorelbine | TUBB | TUBB | 0.000593 | uM | 7787.018 | 0.9106 | 0.5624 | 0.3791 | |
| 184A1 | NM | Basal | Vinorelbine | TUBB | TUBB | 0.00297 | uM | 7787.018 | 0.8751 | 0.4069 | 0.3791 | |
| 184A1 | NM | Basal | Vinorelbine | TUBB | TUBB | 0.0148 | uM | 7787.018 | 0.9194 | 0.6023 | 0.3791 | |
| 184A1 | NM | Basal | Vinorelbine | TUBB | TUBB | 0.0742 | uM | 7787.018 | 0.9558 | 0.7750 | 0.3791 | |
| 184A1 | NM | Basal | Vinorelbine | TUBB | TUBB | 0.371 | uM | 7787.018 | 1.0548 | 1.3020 | 0.3791 |