Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7463.065 | 1.0029 | 1.0110 | 0.5226 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7463.065 | 0.9871 | 0.9511 | 0.5226 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7463.065 | 0.9405 | 0.7785 | 0.5226 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7463.065 | 0.0888 | -0.9806 | 0.5226 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7463.065 | 0.0127 | -0.9995 | 0.5226 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7463.065 | 0.0150 | -0.9994 | 0.5226 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7463.065 | 0.0147 | -0.9994 | 0.5226 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7464.065 | 0.9765 | 0.9343 | 0.7107 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7464.065 | 1.0358 | 1.1014 | 0.7107 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7464.065 | 0.9793 | 0.9421 | 0.7107 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7464.065 | 1.0233 | 1.0658 | 0.7107 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7464.065 | 0.9554 | 0.8755 | 0.7107 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7464.065 | 0.2341 | -0.7407 | 0.7107 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7464.065 | 0.0164 | -0.9938 | 0.7107 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7464.065 | 0.0166 | -0.9938 | 0.7107 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7464.065 | 0.0188 | -0.9926 | 0.7107 | |
| HCC3153 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7465.065 | 1.0600 | 1.0994 | 1.2013 | |
| HCC3153 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7465.065 | 0.9729 | 0.9547 | 1.2013 | |
| HCC3153 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7465.065 | 1.0095 | 1.0157 | 1.2013 | |
| HCC3153 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7465.065 | 0.9771 | 0.9618 | 1.2013 | |
| HCC3153 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 8 | uM | 7465.065 | 0.9354 | 0.8919 | 1.2013 | |
| HCC3153 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 40 | uM | 7465.065 | 0.3499 | -0.1656 | 1.2013 | |
| HCC3153 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 200 | uM | 7465.065 | 0.1368 | -0.6181 | 1.2013 | |
| HCC3153 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1000 | uM | 7465.065 | 0.0770 | -0.7633 | 1.2013 | |
| HCC3153 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 5000 | uM | 7465.065 | 0.0403 | -0.8618 | 1.2013 |