Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9878.012 | 0.7416 | 0.5725 | 1.2431 | |
| SUM52PE | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9878.012 | 0.5924 | 0.3126 | 1.2431 | |
| SUM52PE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9889.012 | 1.1078 | 1.1555 | 1.3671 | |
| SUM52PE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9889.012 | 0.9699 | 0.9558 | 1.3671 | |
| SUM52PE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9889.012 | 1.1061 | 1.1532 | 1.3671 | |
| SUM52PE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9889.012 | 0.9796 | 0.9701 | 1.3671 | |
| SUM52PE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9889.012 | 0.7042 | 0.5475 | 1.3671 | |
| SUM52PE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9889.012 | 0.6925 | 0.5287 | 1.3671 | |
| SUM52PE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9889.012 | 0.6558 | 0.4689 | 1.3671 | |
| SUM52PE | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9889.012 | 0.6451 | 0.4514 | 1.3671 | |
| SUM52PE | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9889.012 | 0.6131 | 0.3984 | 1.3671 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9033.05 | 0.9809 | 0.9706 | 1.3061 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9033.05 | 1.0018 | 1.0028 | 1.3061 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9033.05 | 0.9862 | 0.9788 | 1.3061 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9033.05 | 0.9233 | 0.8814 | 1.3061 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9033.05 | 0.9719 | 0.9569 | 1.3061 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9033.05 | 0.9567 | 0.9333 | 1.3061 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9033.05 | 0.9630 | 0.9431 | 1.3061 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9033.05 | 0.9791 | 0.9679 | 1.3061 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9033.05 | 0.9298 | 0.8916 | 1.3061 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9897.012 | 1.0019 | 1.0081 | 0.4748 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9897.012 | 0.9816 | 0.9232 | 0.4748 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9897.012 | 0.9613 | 0.8405 | 0.4748 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9897.012 | 0.9514 | 0.8009 | 0.4748 | |
| T47D | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9897.012 | 0.9932 | 0.9715 | 0.4748 |