Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9648.012 | 1.0260 | 1.0943 | 0.5579 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9648.012 | 1.0840 | 1.3112 | 0.5579 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9648.012 | 0.9546 | 0.8401 | 0.5579 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 10095.012 | 0.9929 | 0.9842 | 0.8966 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 10095.012 | 0.9978 | 0.9950 | 0.8966 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 10095.012 | 0.9926 | 0.9834 | 0.8966 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 10095.012 | 0.9949 | 0.9887 | 0.8966 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 10095.012 | 0.9712 | 0.9358 | 0.8966 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 10095.012 | 0.9703 | 0.9338 | 0.8966 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 10095.012 | 0.9262 | 0.8361 | 0.8966 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 10095.012 | 0.9005 | 0.7793 | 0.8966 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 10095.012 | 0.8719 | 0.7165 | 0.8966 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7897.012 | 0.9810 | 0.9514 | 0.7808 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7897.012 | 0.9556 | 0.8871 | 0.7808 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7897.012 | 0.9822 | 0.9546 | 0.7808 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7897.012 | 1.0031 | 1.0081 | 0.7808 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7897.012 | 0.9772 | 0.9417 | 0.7808 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7897.012 | 0.9375 | 0.8414 | 0.7808 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7897.012 | 0.7733 | 0.4388 | 0.7808 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7897.012 | 0.7171 | 0.3063 | 0.7808 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7897.012 | 0.7279 | 0.3317 | 0.7808 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7897.036 | 0.9974 | 0.9935 | 0.8072 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7897.036 | 0.9262 | 0.8187 | 0.8072 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7897.036 | 0.9187 | 0.8006 | 0.8072 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7897.036 | 1.0048 | 1.0119 | 0.8072 |