Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 10264.024 | 0.7718 | 0.6181 | 1.2223 | |
| MB 157 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.0000427 | uM | 9039.05 | 0.9399 | 0.7308 | 0.4285 | |
| MB 157 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.000213 | uM | 9039.05 | 1.0628 | 1.3057 | 0.4285 | |
| MB 157 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.00107 | uM | 9039.05 | 0.9696 | 0.8609 | 0.4285 | |
| MB 157 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.00533 | uM | 9039.05 | 0.8999 | 0.5636 | 0.4285 | |
| MB 157 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.0267 | uM | 9039.05 | 0.8652 | 0.4265 | 0.4285 | |
| MB 157 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.133 | uM | 9039.05 | 0.7252 | -0.0551 | 0.4285 | |
| MB 157 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.667 | uM | 9039.05 | 0.8599 | 0.4064 | 0.4285 | |
| MB 157 | Unknown | Unknown | Trametinib | MEK | MAPK | 3.33 | uM | 9039.05 | 0.8065 | 0.2107 | 0.4285 | |
| MB 157 | Unknown | Unknown | Trametinib | MEK | MAPK | 16.7 | uM | 9039.05 | 0.6611 | -0.2387 | 0.4285 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 7867.036 | 0.9328 | 0.9379 | 2.2053 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 7867.036 | 1.0413 | 1.0370 | 2.2053 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 7867.036 | 0.9198 | 0.9256 | 2.2053 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 7867.036 | 0.6005 | 0.5871 | 2.2053 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 7867.036 | 0.3496 | 0.2419 | 2.2053 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 7867.036 | 0.2904 | 0.1417 | 2.2053 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 7867.036 | 0.2972 | 0.1537 | 2.2053 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 7867.036 | 0.2736 | 0.1113 | 2.2053 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 7867.036 | 0.2015 | -0.0327 | 2.2053 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 7868.05 | 0.9997 | 0.9997 | 2.0672 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 7868.05 | 1.0341 | 1.0327 | 2.0672 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 7868.05 | 1.0338 | 1.0325 | 2.0672 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 7868.05 | 0.6998 | 0.6828 | 2.0672 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 7868.05 | 0.3644 | 0.2272 | 2.0672 | |
| MCF 10A | NM | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 7868.05 | 0.2977 | 0.1129 | 2.0672 |