Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.107 | uM | 10581.141 | 0.9687 | 0.9017 | 0.6310 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.533 | uM | 10581.141 | 0.9632 | 0.8845 | 0.6310 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 2.67 | uM | 10581.141 | 0.8994 | 0.6905 | 0.6310 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 13.3 | uM | 10581.141 | 0.6687 | 0.0570 | 0.6310 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 66.7 | uM | 10581.141 | 0.1247 | -0.9262 | 0.6310 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000171 | uM | 11854.158 | 1.0034 | 1.0049 | 1.3776 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000853 | uM | 11854.158 | 0.9916 | 0.9877 | 1.3776 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.00427 | uM | 11854.158 | 1.0002 | 1.0003 | 1.3776 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0213 | uM | 11854.158 | 1.0122 | 1.0177 | 1.3776 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.107 | uM | 11854.158 | 0.9793 | 0.9699 | 1.3776 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.533 | uM | 11854.158 | 0.9662 | 0.9507 | 1.3776 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 2.67 | uM | 11854.158 | 0.8274 | 0.7430 | 1.3776 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 13.3 | uM | 11854.158 | 0.8106 | 0.7173 | 1.3776 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 66.7 | uM | 11854.158 | 0.4998 | 0.2089 | 1.3776 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000171 | uM | 12056.158 | 0.9852 | 0.9702 | 0.9929 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000853 | uM | 12056.158 | 0.9691 | 0.9377 | 0.9929 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.00427 | uM | 12056.158 | 0.9667 | 0.9330 | 0.9929 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0213 | uM | 12056.158 | 0.9504 | 0.9001 | 0.9929 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.107 | uM | 12056.158 | 0.9989 | 0.9979 | 0.9929 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.533 | uM | 12056.158 | 0.9033 | 0.8054 | 0.9929 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 2.67 | uM | 12056.158 | 0.8821 | 0.7626 | 0.9929 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 13.3 | uM | 12056.158 | 0.9528 | 0.9049 | 0.9929 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 66.7 | uM | 12056.158 | 0.6414 | 0.2787 | 0.9929 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000171 | uM | 12178.158 | 1.0404 | 1.1103 | 0.7379 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000853 | uM | 12178.158 | 0.9343 | 0.8240 | 0.7379 |