Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 0.0213 | uM | 12098.158 | 0.9028 | 0.8290 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 0.107 | uM | 12098.158 | 0.9756 | 0.9573 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 0.533 | uM | 12098.158 | 0.8163 | 0.6748 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 2.67 | uM | 12098.158 | 0.4850 | 0.0623 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 13.3 | uM | 12098.158 | 0.2642 | -0.3753 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 66.7 | uM | 12098.158 | 0.0073 | -0.9729 | 1.1438 | |
| SUM229PE | TNBC | - | Sigma A6730 | AKT | AKT | 0.000171 | uM | 11058.158 | 0.9005 | 0.9027 | 2.1018 | |
| SUM229PE | TNBC | - | Sigma A6730 | AKT | AKT | 0.000853 | uM | 11058.158 | 0.9463 | 0.9481 | 2.1018 | |
| SUM229PE | TNBC | - | Sigma A6730 | AKT | AKT | 0.00427 | uM | 11058.158 | 0.8898 | 0.8919 | 2.1018 | |
| SUM229PE | TNBC | - | Sigma A6730 | AKT | AKT | 0.0213 | uM | 11058.158 | 0.9613 | 0.9628 | 2.1018 | |
| SUM229PE | TNBC | - | Sigma A6730 | AKT | AKT | 0.107 | uM | 11058.158 | 0.9530 | 0.9547 | 2.1018 | |
| SUM229PE | TNBC | - | Sigma A6730 | AKT | AKT | 0.533 | uM | 11058.158 | 0.8407 | 0.8415 | 2.1018 | |
| SUM229PE | TNBC | - | Sigma A6730 | AKT | AKT | 2.67 | uM | 11058.158 | 0.8434 | 0.8443 | 2.1018 | |
| SUM229PE | TNBC | - | Sigma A6730 | AKT | AKT | 13.3 | uM | 11058.158 | 0.5870 | 0.5522 | 2.1018 | |
| SUM229PE | TNBC | - | Sigma A6730 | AKT | AKT | 66.7 | uM | 11058.158 | 0.0098 | -0.7786 | 2.1018 | |
| SUM52PE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.000171 | uM | 10695.153 | 0.9708 | 0.9583 | 1.4050 | |
| SUM52PE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.000853 | uM | 10695.153 | 0.9645 | 0.9492 | 1.4050 | |
| SUM52PE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.00427 | uM | 10695.153 | 0.9541 | 0.9342 | 1.4050 | |
| SUM52PE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.0213 | uM | 10695.153 | 0.9805 | 0.9722 | 1.4050 | |
| SUM52PE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.107 | uM | 10695.153 | 1.0063 | 1.0090 | 1.4050 | |
| SUM52PE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.533 | uM | 10695.153 | 0.8569 | 0.7918 | 1.4050 | |
| SUM52PE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 2.67 | uM | 10695.153 | 0.4514 | 0.1355 | 1.4050 | |
| SUM52PE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 13.3 | uM | 10695.153 | 0.2643 | -0.2243 | 1.4050 | |
| SUM52PE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 66.7 | uM | 10695.153 | 0.0177 | -0.8869 | 1.4050 | |
| SUM52PE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.000171 | uM | 11852.158 | 1.0321 | 1.0485 | 1.3172 |