Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Selumetinib | MEK | MAPK | 0.08 | uM | 11854.155 | 0.9200 | 0.8793 | 1.3396 | |
| BT-20 | TNBC | Basal A | Selumetinib | MEK | MAPK | 0.4 | uM | 11854.155 | 0.9781 | 0.9671 | 1.3396 | |
| BT-20 | TNBC | Basal A | Selumetinib | MEK | MAPK | 2 | uM | 11854.155 | 0.8313 | 0.7424 | 1.3396 | |
| BT-20 | TNBC | Basal A | Selumetinib | MEK | MAPK | 10 | uM | 11854.155 | 0.9627 | 0.9440 | 1.3396 | |
| BT-20 | TNBC | Basal A | Selumetinib | MEK | MAPK | 50 | uM | 11854.155 | 0.9425 | 0.9135 | 1.3396 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 12056.155 | 1.0003 | 1.0007 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 12056.155 | 0.9152 | 0.7963 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 12056.155 | 0.9920 | 0.9806 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 12056.155 | 0.9264 | 0.8231 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 12056.155 | 0.9868 | 0.9680 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 12056.155 | 0.9118 | 0.7882 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 12056.155 | 0.9090 | 0.7817 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 12056.155 | 0.9490 | 0.8769 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 12056.155 | 0.8731 | 0.6967 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 12178.155 | 0.9554 | 0.8954 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 12178.155 | 0.8646 | 0.6849 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 12178.155 | 0.9475 | 0.8769 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 12178.155 | 0.9704 | 0.9306 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 12178.155 | 0.9391 | 0.8572 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 12178.155 | 0.9045 | 0.7770 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 12178.155 | 0.8697 | 0.6966 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 12178.155 | 0.9798 | 0.9525 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 12178.155 | 0.8956 | 0.7564 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 12291.155 | 1.0442 | 1.2002 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 12291.155 | 1.0604 | 1.2762 | 0.4532 |