Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 12291.155 | 1.0444 | 1.2013 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 12291.155 | 1.0252 | 1.1127 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 12291.155 | 1.0179 | 1.0798 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 12291.155 | 1.0524 | 1.2387 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 12291.155 | 0.9853 | 0.9357 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 12291.155 | 0.9757 | 0.8945 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 12291.155 | 1.0154 | 1.0684 | 0.4532 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 10696.146 | 0.9766 | 0.9077 | 0.5009 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 10696.146 | 0.9251 | 0.7120 | 0.5009 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 10696.146 | 0.9936 | 0.9744 | 0.5009 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 10696.146 | 0.9623 | 0.8524 | 0.5009 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 10696.146 | 0.9657 | 0.8655 | 0.5009 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 10696.146 | 0.9469 | 0.7937 | 0.5009 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 10696.146 | 0.9705 | 0.8841 | 0.5009 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 10696.146 | 0.9102 | 0.6573 | 0.5009 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 10696.146 | 0.8975 | 0.6118 | 0.5009 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 11855.155 | 0.8836 | 0.7091 | 0.7873 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 11855.155 | 0.8375 | 0.5967 | 0.7873 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 11855.155 | 0.9385 | 0.8450 | 0.7873 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 11855.155 | 0.8868 | 0.7170 | 0.7873 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 11855.155 | 0.8684 | 0.6718 | 0.7873 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 11855.155 | 0.9186 | 0.7954 | 0.7873 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 11855.155 | 0.8190 | 0.5519 | 0.7873 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 11855.155 | 0.9101 | 0.7745 | 0.7873 | |
| BT-483 | HR+ | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 11855.155 | 0.9604 | 0.8999 | 0.7873 |