Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7516.095 | 0.9731 | 0.9598 | 1.3423 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7516.095 | 0.8611 | 0.7892 | 1.3423 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7516.095 | 0.6986 | 0.5310 | 1.3423 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7516.095 | 0.4712 | 0.1417 | 1.3423 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7516.095 | 0.9022 | 0.8524 | 1.3423 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7517.095 | 0.6932 | 0.5756 | 1.5365 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7517.095 | 0.7346 | 0.6363 | 1.5365 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7517.095 | 0.6962 | 0.5800 | 1.5365 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7517.095 | 0.6675 | 0.5374 | 1.5365 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7517.095 | 0.7353 | 0.6373 | 1.5365 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7517.095 | 0.6961 | 0.5799 | 1.5365 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7517.095 | 0.6391 | 0.4945 | 1.5365 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7517.095 | 0.7227 | 0.6190 | 1.5365 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7517.095 | 0.8236 | 0.7626 | 1.5365 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7518.095 | 0.9314 | 0.9040 | 1.4438 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7518.095 | 0.9858 | 0.9802 | 1.4438 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7518.095 | 0.9160 | 0.8821 | 1.4438 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7518.095 | 0.9387 | 0.9142 | 1.4438 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7518.095 | 0.9483 | 0.9278 | 1.4438 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7518.095 | 0.9578 | 0.9412 | 1.4438 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7518.095 | 0.9337 | 0.9073 | 1.4438 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7518.095 | 0.8976 | 0.8558 | 1.4438 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7518.095 | 0.9453 | 0.9236 | 1.4438 | |
| MX1 | Unknown | Unknown | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7523.095 | 1.0132 | 1.0322 | 0.8203 | |
| MX1 | Unknown | Unknown | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7523.095 | 1.0120 | 1.0293 | 0.8203 |