Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | PD173074 | FGFR1/3 | RTK | 13.3 | uM | 10579.1 | 0.7678 | 0.5222 | 0.9677 | |
| SUM225CWN | HER2amp | Basal A | PD173074 | FGFR1/3 | RTK | 66.7 | uM | 10579.1 | 0.1042 | -0.8067 | 0.9677 | |
| SUM229PE | TNBC | - | PD173074 | FGFR1/3 | RTK | 0.000171 | uM | 7535.1 | 1.0313 | 1.0718 | 0.8740 | |
| SUM229PE | TNBC | - | PD173074 | FGFR1/3 | RTK | 0.000853 | uM | 7535.1 | 0.9097 | 0.7947 | 0.8740 | |
| SUM229PE | TNBC | - | PD173074 | FGFR1/3 | RTK | 0.00427 | uM | 7535.1 | 0.9800 | 0.9542 | 0.8740 | |
| SUM229PE | TNBC | - | PD173074 | FGFR1/3 | RTK | 0.0213 | uM | 7535.1 | 1.0020 | 1.0045 | 0.8740 | |
| SUM229PE | TNBC | - | PD173074 | FGFR1/3 | RTK | 0.107 | uM | 7535.1 | 0.9695 | 0.9304 | 0.8740 | |
| SUM229PE | TNBC | - | PD173074 | FGFR1/3 | RTK | 0.533 | uM | 7535.1 | 0.9319 | 0.8450 | 0.8740 | |
| SUM229PE | TNBC | - | PD173074 | FGFR1/3 | RTK | 2.67 | uM | 7535.1 | 0.9602 | 0.9092 | 0.8740 | |
| SUM229PE | TNBC | - | PD173074 | FGFR1/3 | RTK | 13.3 | uM | 7535.1 | 0.5438 | -0.0037 | 0.8740 | |
| SUM229PE | TNBC | - | PD173074 | FGFR1/3 | RTK | 66.7 | uM | 7535.1 | 0.0147 | -0.9840 | 0.8740 | |
| SUM52PE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 7539.093 | 0.9892 | 0.9864 | 1.5919 | |
| SUM52PE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.000427 | uM | 7539.093 | 0.8634 | 0.8237 | 1.5919 | |
| SUM52PE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.00213 | uM | 7539.093 | 0.9124 | 0.8880 | 1.5919 | |
| SUM52PE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 7539.093 | 0.8024 | 0.7417 | 1.5919 | |
| SUM52PE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 7539.093 | 0.4167 | 0.1541 | 1.5919 | |
| SUM52PE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.267 | uM | 7539.093 | 0.4253 | 0.1690 | 1.5919 | |
| SUM52PE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 1.33 | uM | 7539.093 | 0.4403 | 0.1947 | 1.5919 | |
| SUM52PE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 6.67 | uM | 7539.093 | 0.3215 | -0.0194 | 1.5919 | |
| SUM52PE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 33.3 | uM | 7539.093 | 0.1395 | -0.4197 | 1.5919 | |
| T47D | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.000171 | uM | 7542.1 | 1.0486 | 1.0732 | 1.3201 | |
| T47D | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.000853 | uM | 7542.1 | 1.0033 | 1.0051 | 1.3201 | |
| T47D | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.00427 | uM | 7542.1 | 0.9969 | 0.9952 | 1.3201 | |
| T47D | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0213 | uM | 7542.1 | 0.9786 | 0.9676 | 1.3201 | |
| T47D | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.107 | uM | 7542.1 | 1.0353 | 1.0533 | 1.3201 |