Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.0032 | uM | 12239.152 | 0.9417 | 0.9464 | 2.2104 | |
| HCC1806 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.016 | uM | 12239.152 | 0.8841 | 0.8916 | 2.2104 | |
| HCC1806 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.08 | uM | 12239.152 | 0.9205 | 0.9264 | 2.2104 | |
| HCC1806 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.4 | uM | 12239.152 | 0.9693 | 0.9720 | 2.2104 | |
| HCC1806 | TNBC | Basal A | PD 98059 | MEK | MAPK | 2 | uM | 12239.152 | 0.9875 | 0.9887 | 2.2104 | |
| HCC1806 | TNBC | Basal A | PD 98059 | MEK | MAPK | 10 | uM | 12239.152 | 0.9076 | 0.9141 | 2.2104 | |
| HCC1806 | TNBC | Basal A | PD 98059 | MEK | MAPK | 50 | uM | 12239.152 | 0.8986 | 0.9055 | 2.2104 | |
| HCC1937 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.000256 | uM | 11849.159 | 0.9134 | 0.8600 | 1.2484 | |
| HCC1937 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.00128 | uM | 11849.159 | 0.9361 | 0.8969 | 1.2484 | |
| HCC1937 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.0064 | uM | 11849.159 | 0.8990 | 0.8364 | 1.2484 | |
| HCC1937 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.032 | uM | 11849.159 | 0.9048 | 0.8460 | 1.2484 | |
| HCC1937 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.16 | uM | 11849.159 | 0.9057 | 0.8475 | 1.2484 | |
| HCC1937 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.8 | uM | 11849.159 | 0.8755 | 0.7979 | 1.2484 | |
| HCC1937 | TNBC | Basal A | PD 98059 | MEK | MAPK | 4 | uM | 11849.159 | 0.8445 | 0.7468 | 1.2484 | |
| HCC1937 | TNBC | Basal A | PD 98059 | MEK | MAPK | 20 | uM | 11849.159 | 0.7533 | 0.5940 | 1.2484 | |
| HCC1937 | TNBC | Basal A | PD 98059 | MEK | MAPK | 100 | uM | 11849.159 | 0.5929 | 0.3158 | 1.2484 | |
| HCC1954 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 0.000128 | uM | 11055.152 | 0.9848 | 0.9817 | 1.6647 | |
| HCC1954 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 0.00064 | uM | 11055.152 | 1.0409 | 1.0487 | 1.6647 | |
| HCC1954 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 0.0032 | uM | 11055.152 | 1.0196 | 1.0235 | 1.6647 | |
| HCC1954 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 0.016 | uM | 11055.152 | 0.9784 | 0.9740 | 1.6647 | |
| HCC1954 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 0.08 | uM | 11055.152 | 1.0141 | 1.0169 | 1.6647 | |
| HCC1954 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 0.4 | uM | 11055.152 | 0.9817 | 0.9779 | 1.6647 | |
| HCC1954 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 2 | uM | 11055.152 | 1.0307 | 1.0367 | 1.6647 | |
| HCC1954 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 10 | uM | 11055.152 | 0.9772 | 0.9725 | 1.6647 | |
| HCC1954 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 50 | uM | 11055.152 | 0.8346 | 0.7941 | 1.6647 |