Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 5.33 | uM | 10997.147 | 0.7395 | 0.6069 | 1.3792 | |
| MCF7 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 26.7 | uM | 10997.147 | 0.0955 | -0.6358 | 1.3792 | |
| MCF7 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 133 | uM | 10997.147 | 0.0982 | -0.6284 | 1.3792 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 10998.147 | 0.9759 | 0.9439 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 10998.147 | 0.9305 | 0.8387 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 10998.147 | 0.9949 | 0.9882 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 10998.147 | 1.0262 | 1.0613 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.213 | uM | 10998.147 | 0.9953 | 0.9890 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 1.07 | uM | 10998.147 | 1.0306 | 1.0715 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 5.33 | uM | 10998.147 | 0.8799 | 0.7228 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 26.7 | uM | 10998.147 | 0.4599 | -0.1918 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 133 | uM | 10998.147 | 0.4868 | -0.1364 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 12206.147 | 1.0300 | 1.0660 | 0.9103 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 12206.147 | 0.9807 | 0.9576 | 0.9103 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 12206.147 | 1.0406 | 1.0894 | 0.9103 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 12206.147 | 1.0255 | 1.0561 | 0.9103 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.213 | uM | 12206.147 | 1.0805 | 1.1776 | 0.9103 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 1.07 | uM | 12206.147 | 1.0531 | 1.1169 | 0.9103 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 5.33 | uM | 12206.147 | 0.8239 | 0.6167 | 0.9103 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 26.7 | uM | 12206.147 | 0.3519 | -0.3650 | 0.9103 | |
| MDA-MB-134-VI | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 133 | uM | 12206.147 | 0.3719 | -0.3253 | 0.9103 | |
| MDA-MB-157 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 12594.147 | 0.9677 | 0.9546 | 1.4279 | |
| MDA-MB-157 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 12594.147 | 0.9829 | 0.9760 | 1.4279 | |
| MDA-MB-157 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 12594.147 | 1.0148 | 1.0207 | 1.4279 | |
| MDA-MB-157 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 12594.147 | 1.0920 | 1.1271 | 1.4279 |